Microvesicle-associated and circulating microRNAs in diabetic dyslipidemia: miR-218, miR-132, miR-143, and miR-21, miR-122, miR-155 have biomarker potential

Nemecz, Miruna; Stefan, Diana Simona; Comarița, Ioana Karla; Constantin, Alina; Tanko, Gabriela; Guja, Cristian; Georgescu, Adriana

doi:10.1186/s12933-023-01988-0

Cardiovascular Diabetology

Table 11 Significant correlations among MV miRNAs and plasma miRNAs in the diabetic dyslipidemia context

From: Microvesicle-associated and circulating microRNAs in diabetic dyslipidemia: miR-218, miR-132, miR-143, and miR-21, miR-122, miR-155 have biomarker potential

T₂D-DLP group		MV miR-21	MV miR-34a	MV miR-132	MV miR-143	MV miR-223	MV miR-122	MV miR-126	MV miR-155	MV miR-200b	MV miR-212	MV miR-218
Plasma miRNAs ↓	n	17	17	17	17	17	17	17	17	17	17	17
Plasma miR-21	r	0.301	− 0.314	0.412	0.022	0.951	− 0.531	− 0.521	− 0.221	− 0.031	0.014	0.142
Plasma miR-21	P	0.612	0.614	0.481	0.961	0.012	0.350	0.361	0.711	0.952	0.972	0.812
Plasma miR-34a	r	0.263	− 0.032	0.410	0.462	0.610	0.022	− 0.510	− 0.204	− 0.112	0.391	0.251
Plasma miR-34a	P	0.661	0.951	0.483	0.420	0.263	0.970	0.371	0.731	0.851	0.504	0.683
Plasma miR-132	r	− 0.361	0.274	0.880	0.761	0.490	0.1630	− 0.501	− 0.583	0.063	0.114	0.761
Plasma miR-132	P	0.542	0.652	0.042	0.130	0.391	0.781	0.384	0.304	0.912	0.852	0.122
Plasma miR-143	r	0.310	0.271	− 0.642	− 0.5023	− 0.230	− 0.220	0.832	− 0.061	0.591	− 0.383	− 0.843
Plasma miR-143	P	0.601	0.652	0.231	0.380	0.702	0.714	0.073	0.914	0.282	0.522	0.071
Plasma miR-223	r	− 0.260	0.373	− 0.440	0.031	− 0.980	0.600	0.561	0.212	0.051	0.043	− 0.192
Plasma miR-223	P	0.663	0.530	0.443	0.950	0.002	0.272	0.321	0.721	0.920	0.941	0.751
Plasma miR-122	r	0.011	0.621	− 0.470	− 0.103	− 04.52	0.190	0.901	− 0.233	0.664	− 0.283	− 0.582
Plasma miR-122	P	0.980	0.260	0.412	0.860	0.035	0.744	0.032	0.704	0.212	0.641	0.291
Plasma miR-126	r	0.122	− 0.083	0.010	− 0.603	0.612	− 0.904	0.281	− 0.381	0.560	− 0.754	− 0.342
Plasma miR-126	P	0.840	0.890	0.971	0.280	0.250	0.034	0.640	0.521	0.323	0.140	0.561
Plasma miR-155	r	− 0.321	0.381	− 0.280	0.274	− 0.97	0.782	0.362	0.213	− 0.082	0.230	0.025
Plasma miR-155	P	0.581	0.510	0.644	0.650	0.003	0.110	0.540	0.730	0.891	0.700	0.960
Plasma miR-200b	r	− 0.744	0.142	0.392	0.214	− 0.351	0.232	− 0.071	− 0.122	− 0.083	− 0.211	0.611
Plasma miR-200b	P	0.141	0.814	0.501	0.720	0.554	0.701	0.902	0.840	0.894	0.724	0.263
Plasma miR-212	r	− 0.022	0.344	0.324	0.014	0.592	− 0.464	0.243	− 0.701	0.692	− 0.502	− 0.071
Plasma miR-212	P	0.972	0.573	0.591	0.980	0.290	0.422	0.691	0.182	0.193	0.381	0.904
Plasma miR-218	r	0.651	− 0.173	− 0.404	− 0.522	0.471	− 0.593	0.254	− 0.014	0.311	− 0.183	− 0.712
Plasma miR-218	P	0.224	0.770	0.493	0.360	0.414	0.281	0.672	0.981	0.614	0.761	0.170

Spearman rank correlation test was used to assess relat1ionships among variables. Bolded coefficients show a powerful correlation, and of them only italic underlined coefficients are significant (p < 0.05)

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