Microvesicle-associated and circulating microRNAs in diabetic dyslipidemia: miR-218, miR-132, miR-143, and miR-21, miR-122, miR-155 have biomarker potential

Table 10 Significant correlations among circulating/plasma MVs and miRNAs in the diabetic dyslipidemia context

T₂D-DLP group		ErMVs	PMVs	LeMVs	MMVs	EMVs	total MVs
Plasma miRNAs ↓	n	17	17	17	17	17	17
Plasma miR-21	r	0.461	− 0.011	0.101	− 0.434	0.263	0.602
Plasma miR-21	P	0.425	0.982	0.872	0.462	0.672	0.271
Plasma miR-34a	r	− 0.022	0.291	− 0.264	− 0.050	0.154	− 0.820
Plasma miR-34a	P	0.971	0.633	0.664	0.921	0.793	0.083
Plasma miR-132	r	− 0.792	− 0.401	− 0.274	0.580	− 0.490	− 0.601
Plasma miR-132	P	0.101	0.490	0.642	0.292	0.394	0.270
Plasma miR-143	r	− 0.750	− 0.614	0.223	− 0.191	− 0.650	− 0.472
Plasma miR-143	P	0.141	0.262	0.712	0.750	0.223	0.410
Plasma miR-223	r	− 0.162	− 0.114	− 0.590	0.603	0.054	− 0.134
Plasma miR-223	P	0.780	0.852	0.281	0.281	0.930	0.830
Plasma miR-122	r	− 0.401	− 0.480	0.672	− 0.682	− 0.552	− 0.044
Plasma miR-122	P	0.503	0.403	0.210	0.203	0.331	0.940
Plasma miR-126	r	0.754	0.860	− 0.331	− 0.122	0.760	− 0.392
Plasma miR-126	P	0.162	0.051	0.580	0.840	0.132	0.504
Plasma miR-155	r	0.174	− 0.282	0.692	− 0.513	− 0.181	0.972
Plasma miR-155	P	0.782	0.630	0.190	0.370	0.753	0.005
Plasma miR-200b	r	0.393	0.751	− 0.752	0.311	0.674	− 0.843
Plasma miR-200b	P	0.501	0.133	0.134	0.600	0.212	0.074
Plasma miR-212	r	− 0.352	− 0.783	0.741	− 0.712	− 0.621	0.553
Plasma miR-212	P	0.550	0.111	0.142	0.170	0.260	0.334
Plasma miR-218	r	− 0.942	− 0.630	0.121	0.394	− 0.773	− 0.331
Plasma miR-218	P	0.011	0.244	0.843	0.514	0.121	0.570

Spearman rank correlation test was used to assess relationships among variables. Bolded coefficients show a powerful correlation, and of them only italic underlined coefficients are significant (p < 0.05)

ISSN: 1475-2840