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Table 4 Associations of the cumulative TyG-BMI with stroke stratified by different factors

From: Changes in the triglyceride glucose-body mass index estimate the risk of stroke in middle-aged and older Chinese adults: a nationwide prospective cohort study

Subgroup

Cumulative TyG-BMI, OR (95% CI)

P for trenda

P for interaction

Quartile 1

[353, 534]

Quartile 2

(534, 608]

Quartile 3

(608, 693]

Quartile 4

(693, 1130]

Age (years)

     

0.151

 < 60

Reference

2.59 (1.20–5.56)

2.14 (0.97–4.70)

2.43 (1.07–5.49)

0.188

 

 ≥ 60

Reference

1.41 (0.86–2.32)

1.20 (0.70–2.08)

0.96 (0.51–1.81)

0.735

 

Sex

     

0.354

 Male

Reference

1.74 (0.97–3.12)

2.12 (1.14–3.94)

1.41 (0.66–3.01)

0.339

 

 Female

Reference

1.46 (0.82–2.60)

0.93 (0.51–1.72)

1.14 (0.61–2.14)

0.860

 

Marital status

     

0.008

 Married

Reference

2.04 (1.22–3.39)

2.04 (1.21–3.44)

1.76 (1.00–3.10)

0.256

 

 Other

Reference

1.25 (0.60–2.58)

0.42 (0.15–1.17)

0.65 (0.23–1.78)

0.219

 

Residence

     

0.720

 Urban

Reference

2.11 (0.75–5.95)

1.52 (0.54–4.32)

1.06 (0.35–3.22)

0.285

 

 Rural

Reference

1.53 (0.97–2.40)

1.39 (0.85–2.27)

1.43 (0.83–2.45)

0.337

 

Educational level

     

0.034

 No formal education

Reference

1.19 (0.61–2.33)

0.93 (0.44–1.97)

1.33 (0.60–2.96)

0.564

 

 Primary school

Reference

1.64 (0.89–3.04)

1.69 (0.89–3.22)

1.23 (0.59–2.54)

0.863

 

 Middle or high school

Reference

6.49 (1.44–29.29)

5.13 (1.12–23.55)

4.56 (0.94–22.07)

0.464

 

 College or above

Reference

NA

NA

NA

NA

 

Smoking status

     

0.483

 Never

Reference

1.54 (0.88–2.69)

1.00 (0.55–1.81)

1.20 (0.65–2.21)

0.924

 

 Former

Reference

0.89 (0.23–3.43)

1.85 (0.52–6.63)

1.57 (0.36–6.84)

0.444

 

 Current

Reference

1.91 (0.96–3.83)

2.33 (1.09–4.96)

1.23 (0.46–3.26)

0.476

 

Drinking status

     

0.906

 Never

Reference

1.55 (0.89–2.70)

1.30 (0.72–2.32)

1.26 (0.68–2.35)

0.865

 

 Former

Reference

1.61 (0.47–5.48)

0.65 (0.16–2.68)

0.75 (0.16–3.62)

0.503

 

 Current

Reference

1.83 (0.90–3.74)

1.90 (0.88–4.12)

1.72 (0.71–4.16)

0.307

 

Hypertension

     

0.241

 No

Reference

1.40 (0.87–2.25)

1.39 (0.82–2.35)

1.51 (0.83–2.74)

0.209

 

 Yes

Reference

3.24 (1.27–8.25)

2.16 (0.85–5.53)

1.82 (0.69–4.80)

0.644

 

Diabetes

     

0.333

 No

Reference

1.69 (1.12–2.56)

1.49 (0.96–2.31)

1.38 (0.84–2.26)

0.479

 

 Yes

Reference

1.00 (0.07–14.33)

0.24 (0.01–4.70)

0.78 (0.05–11.40)

0.927

 

Heart disease

     

0.709

 No

Reference

1.53 (0.99–2.36)

1.36 (0.85–2.16)

1.32 (0.79–2.20)

0.535

 

 Yes

Reference

2.52 (0.74–8.58)

1.58 (0.44–5.72)

1.62 (0.44–6.00)

0.991

 

Dyslipidaemia

     

0.591

 No

Reference

1.59 (1.05–2.43)

1.38 (0.88–2.18)

1.28 (0.77–2.12)

0.626

 

 Yes

Reference

4.38 (0.49–38.93)

2.78 (0.32–24.24)

2.92 (0.33–25.81)

0.983

 

Kidney disease

     

0.066

 No

Reference

1.48 (0.97–2.24)

1.30 (0.84–2.02)

1.26 (0.78–2.04)

0.659

0.151

 Yes

Reference

NA

NA

NA

NA

 
  1. BMI: body mass index; CI: confidence interval; OR: odds ratio; TyG: triglyceride-glucose; NA: not applicable
  2. All models were adjusted for age, sex, marital status, residence, educational level, smoking status, drinking status, history of hypertension, diabetes, heart disease, dyslipidaemia, kidney disease, medication use for hypertension, medication use for diabetes, medication use for dyslipidaemia, systolic blood pressure, diastolic blood pressure, total cholesterol, HDL-C, LDL-C, HbA1c, and the eGFR
  3. aTests for linear trends were performed by modelling the median value of each quantile to test ordered relations across quantiles of cumulative TyG-BMI
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Cardiovascular Diabetology

ISSN: 1475-2840