Temporal trends in chronic complications of diabetes by sex in community-based people with type 2 diabetes: the Fremantle Diabetes Study

Table 1 Five-year incidence rate ratios (IRR) for outcomes in pooled FDS1 and FDS2 participants with type 2 diabetes and without diabetes including main effects (sex, diabetes status, FDS phase) and their two- and three-way interactions adjusted for age

	MI		Stroke		HF		LEA		CVD death		All-cause death
	IRR (95% CI)	P-value	IRR (95% CI)	P-value	IRR (95% CI)	P-value	IRR (95% CI)	P-value	IRR (95% CI)	P-value	IRR (95% CI)	P-value
Age (1 year increase)	1.07 (1.06, 1.08)	< 0.001	1.09 (1.08, 1.10)	< 0.001	1.10 (1.09, 1.11)	< 0.001	1.01 (0.99, 1.04)	0.292	1.11 (1.10, 1.12)	< 0.001	1.10 (1.09, 1.10)	< 0.001
Male (vs female)	1.87 (1.46, 2.41)	< 0.001	1.95 (1.30, 2.91)	0.001	1.15 (0.94, 1.42)	0.167	1.06 (0.31, 3.65)	0.928	1.80 (1.37, 2.37)	< 0.001	1.90 (1.63, 2.21)	< 0.001
Diabetes (vs no diabetes)	2.83 (2.09, 3.82)	< 0.001	2.57 (1.56, 4.23)	< 0.001	2.47 (1.97, 3.10)	< 0.001	4.79 (1.47, 15.6)	0.009	2.41 (1.72, 3.40)	< 0.001	1.45 (1.15, 1.83)	0.001
FDS2 (vs FDS1)	0.70 (0.52, 0.94)	0.016	1.19 (0.79, 1.79)	0.394	0.54 (0.43, 0.68)	< 0.001	0.54 (0.13, 2.24)	0.392	0.45 (0.32, 0.63)	< 0.001	0.62 (0.52, 0.75)	< 0.001
Male * diabetes	0.80 (0.54, 1.17)	0.251	0.76 (0.40, 1.46)	0.418	1.00 (0.73, 1.39)	0.977	2.84 (0.61, 13.3)	0.186	0.82 (0.52, 1.29)	0.391	0.83 (0.62, 1.12)	0.226
Male * FDS2	0.97 (0.67, 1.39)	0.863	0.63 (0.37, 1.06)	0.083	1.10 (0.81, 1.50)	0.544	1.17 (0.17, 8.18)	0.873	0.77 (0.48, 1.21)	0.251	0.85 (0.68, 1.07)	0.163
Diabetes * FDS2	0.91 (0.58, 1.43)	0.673	0.46 (0.22, 0.96)	0.037	0.91 (0.63, 1.31)	0.603	1.67 (0.27, 10.3)	0.581	0.70 (0.38, 1.30)	0.260	1.02 (0.72, 1.43)	0.928
Male * diabetes * FDS2	0.79 (0.44, 1.43)	0.433	1.18 (0.44, 3.11)	0.744	1.05 (0.64, 1.72)	0.860	0.53 (0.05, 5.60)	0.596	1.17 (0.52, 2.62)	0.710	1.22 (0.79, 1.89)	0.361

ISSN: 1475-2840