Table 1 Medications with proven CMR benefits and their respective targeted CMR abnormalities. CMR, cardio-metabolic-renal; T2D, type 2 diabetes; HF, heart failure; CKD, chronic kidney disease

SGLT2i

• T2D [128, 132, 136]

• Overweight [132, 136]

• Hypertension [132, 136]

• HF [127, 134, 136]

• CV death [128, 132]

• CKD [127, 131, 132, 142]

• ESKD [127]

• Albuminuria [132, 142]

GLP1 – RA

• T2D [126, 131]

• Overweight/obesity [126, 131]

• Hypertension [126, 134, 137]

• Atherosclerosis [131, 137]

• Stroke [126, 134, 137]

• CV death [131, 137]

• Albuminuria [126, 133, 134]

• CKD? [131, 134]

Finerenone

• T2D (?) [129, 130]

• Hypertension [130]

• HF [129, 130, 135]

• CKD [129, 135]

Tirzepatide

• T2D [138, 139]

• Overweight/obesity [138, 139]

• CV risk factors [138, 143]

• Albuminuria? [144]

• CKD? [144]