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Table 2 HR and 95% CI for the risk of myocardial infarction stratified by time-weighted cumulative AIP, duration of high AIP exposure and time course of AIP accumulation

From: Association between cumulative atherogenic index of plasma exposure and risk of myocardial infarction in the general population

Index

Case, n (%)

Incidence rate, per 1000 person-years

Model 1 HR (95% CI)

Model 2 HR (95% CI)

Model 3 HR (95% CI)

Model 4 HR (95% CI)

Sensitivity analysisa HR (95% CI)

Time-weighted cumulative AIP

 Q1 (≤ -0.50)

108 (0.79)

0.72 (0.60–0.88)

Reference

Reference

Reference

Reference

Reference

 Q2 (-0.50 to -0.12)

168 (1.23)

1.13 (0.97–1.31)

1.56 (1.22–1.99)

1.56 (1.23–1.99)

1.40 (1.09–1.78)

1.39 (1.09–1.78)

1.38 (1.08–1.76)

 Q3 (-0.12 to 0.28)

225 (1.65)

1.52 (1.33–1.73)

2.09 (1.66–2.63)

2.11 (1.68–2.66)

1.71 (1.35–2.17)

1.73 (1.36–2.19)

1.72 (1.35–2.18)

 Q4 (≥ 0.28)

265 (1.95)

1.79 (1.59–2.02)

2.47 (1.97–3.09)

2.62 (2.09–3.28)

1.86 (1.45–2.39)

1.89 (1.47–2.43)

1.91 (1.49–2.45)

P for trend

  

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

Duration of high AIP exposureb

 0 year

328 (1.06)

0.97 (0.87–1.08)

Reference

Reference

Reference

Reference

Reference

 2 years

199 (1.73)

1.58 (1.38–1.82)

1.63 (1.36–1.94)

1.69 (1.42–2.02)

1.45 (1.20–1.74)

1.49 (1.24–1.79)

1.46 (1.21–1.76)

 4 years

133 (1.97)

1.81 (1.53–2.14)

1.86 (1.52–2.27)

1.95 (1.59–2.39)

1.52 (1.22–1.90)

1.57 (1.26–1.96)

1.58 (1.27–1.97)

 6 years

106 (2.01)

1.85 (1.53–2.24)

1.91 (1.53–2.37)

2.04 (1.63–2.54)

1.48 (1.15–1.90)

1.52 (1.18–1.95)

1.54 (1.20–2.00)

 P for trend

  

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

Time course of AIP accumulationc

 Low time-weighted cumulative AIP with positive slope

135 (1.02)

0.93 (0.79–1.11)

Reference

Reference

Reference

Reference

Reference

 Low time-weighted cumulative AIP with negative slope

141 (1.01)

0.92 (0.78–1.09)

0.99 (0.78–1.25)

0.90 (0.71–1.15)

0.88 (0.69–1.11)

0.89 (0.70–1.13)

0.90 (0.71–1.14)

 High time-weighted cumulative AIP with positive slope

233 (1.64)

1.51 (1.33–1.71)

1.61 (1.31–1.99)

1.69 (1.36–2.09)

1.37 (1.10–1.71)

1.36 (1.09–1.69)

1.37 (1.10–1.71)

 High time-weighted cumulative AIP with negative slope

257 (1.97)

1.81 (1.60–2.05)

1.94 (1.58–2.39)

1.80 (1.46–2.22)

1.34 (1.07–1.68)

1.42 (1.13–1.79)

1.44 (1.14–1.81)

 P for trend

  

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.0003

  1. AIP atherogenic index of plasma
  2. Model 1: unadjusted
  3. Model 2: adjusted for age and sex
  4. Model 3: Model 2 plus further adjusted for education, income, smoking status, drinking status, body mass index, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, history of hypertension, hyperlipidemia, diabetes at baseline
  5. Model 4: Model 3 plus further adjusted for high sensitivity C-reactive protein, estimated glomerular filtration rate, total cholesterol, low-density lipoprotein cholesterol level, antihypertensive drugs, antidiabetic drugs, and lipid-lowering drugs at baseline
  6. aSensitivity analysis was adjusted for covariables in Model 4 and further considering death as competing event
  7. bHigh AIP was defined as AIP in the highest quartile
  8. cMedian of cumulative AIP was − 0.12
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Cardiovascular Diabetology

ISSN: 1475-2840