The non-steroidal mineralocorticoid receptor antagonist finerenone and heart failure with preserved ejection fraction

Table 1 [5] Key pharmacodynamic- and kinetic parameters of steroidal MRA and finerenone. MR: mineralocorticoid receptor; MRA: MR-antagonist; CNS: central nervous system; BP: blood pressure

	Steroidal MRA		Non-steroidal MRA
	Spironolactone	Eplerenone	Finerenone
Structural properties	Flat (steroidal)	Flat (steroidal)	Bulky (non-steroidal)
MR-Affinity	+++	+	+++
MR-Selectivity	+	++	+++
Sex-hormone-related side effects	++	(+)	-
CNS penetration	+	+	-
Plasma half-life	> 20 h	4-6 h	2-3 h
Effect on BP	+++	++	+

ISSN: 1475-2840