Table 2 Severity of pulmonary hypertension according to diabetes status

Clinical parameters

WHO-FC N = 530 (99.6%)

I

II

III

IV

29 (7.3%)

191 (48.5%)

155 (39.3%)

19 (4.8%)

1 (0.7%)

33 (24.4%)

77 (57.0%)

24 (17.8%)

< 0.001*

1 (0.7%)

60 (44.1%)

67 (49.2%)

8 (5.9%)

1 (0.7%)

33 (24.4%)

77 (57.0%)

24 (17.8%)

< 0.001*

NT-proBNP (pg/ml)

N = 500 (94.0%)

461 [130–1812]

1628 [470–3058]

< 0.001*

719 [240–2187]

1628 [470–3058]

0.003*

6MWD test (m)

N = 491 (92.3%)

423 [307–504]

301 [177–378]

< 0.001*

335 [220–441]

301 [177–378]

0.03*

Echocardiography

Pericardial effusion

N = 508 (95.5%)

69 (18%)

25 (19%)

0.8

22 (16.8%)

25 (19%)

0.6

RAA (cm²)

N = 487 (91.5%)

22 [18–28]

26 [21.5–32.0]

< 0.001*

24 [19–28.9]

26 [21.5–32.0]

0.04*

TAPSE (mm)

N = 458 (86.1%)

19 [16–22]

19 [16–22]

0.7

19 [16–22]

19 [16–22]

0.8

Right heart catheterization

mPAP (mmHg)

N = 521 (97.9%)

44.5 [35–55]

46 [36–55]

0.5

40 [33–51]

46 [36–55]

0.01*

PAWP (mmHg)

N = 480 (90.2%)

9 [6–12]

9 [7–13]

0.06

10 [7–12]

9 [7–13]

0.9

SvO₂ (%)

N = 488 (91.7%)

69 [64–75]

65 [58–71]

< 0.001*

66 [60–71]

65 [58–71]

0.4

PVR (WU)

N = 513 (96.4%)

7.6 [5.1–11.0]

7.8 [5.2–11]

0.8

6.3 [5–8.7]

7.8 [5.2–11]

0.02*

CI (l/min/m²)

N = 505 (94.9%)

2.6 [2.1–3.2]

2.4 [2.0–2.8]

0.06

2.6 [2.1–2.8]

2.4 [2.0–2.8]

0.3

RAP (mmHg)

N = 505 (94.9%)

6 [4–9]

8 [5–12]

< 0.001*

7 [3–9]

8 [5–12]

0.003*