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Table 4 Distribution of alleles of selected SNPs in subjects with diabetic foot syndrome (DFS), diabetic subjects without diabetic foot syndrome and control subejcts

From: Metabolic memory in diabetic foot syndrome (DFS): MICRO-RNAS, single nucleotide polymorphisms (SNPs) frequency and their relationship with indices of endothelial function and adipo-inflammatory dysfunction

SNP

Allelic variant

DFS (n = 50)

NDFS (n = 40)

Control (n = 20)

p

IL—6

n/%

GG

35/70

20/63

10/53

0.317

GC

14/30

11/34

7/32

0.816

CC

2/2

1/3

3/16

0.175

TNF-α

n/%

GG

44/87

26/81

19/59

0.390

GA

5/10

6/19

0

0.112

AG

0

0

1/4

0.196

VEGF

2578A

n/%

CC

37/74

19/47.5

1/5

0.001

AA

10/20

14/35

6/30

0.152

AC

3/6

7/17.5

13/65

 < 0.0005

VEGF

C936T

n/%

CC

38/77

23/72

13/46

0.645

CT

11/21

8/25

6/14

0.754

TT

1/ 2

1/3

1/ 4

1.000

eNOS

n/%

GG

24/49

13/41

13/45

0.241

TT

3/6

2/6

0

0.652

GT

23/43

17/53

7/21

0.459

HIF-1α

n/%

CC

37/70

28/88

16/55

0.340

CT

13/29

4/13

3/7

0.277

TT

0

0

1/3

0.196

  1. IL-6: Interleukin-6, TNFA-alfa: Tumor necrosis factor alfa; VEGF: Vascular Endothelial Growth Factor: eNOS: endothelial Nitric-Oxid Synthase; HIF-1 alfa: Hypoxia-inducible factor 1-alpha