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Table 2 Risk of incident type 2 diabetes with co-exposure to CumAIP and CumCRP across age subgroups (< 45, 45 – 65, ≥ 65 years)

From: Supra-additive effect of chronic inflammation and atherogenic dyslipidemia on developing type 2 diabetes among young adults: a prospective cohort study

Combination of CumCRP and CumAIP, HRs (95% CIs)

 

CumAIP < − 0.0699 and CumCRP < 1 mg/L

CumAIP < − 0.0699 and 1 ≤ CumCRP < 3 mg/L

CumAIP < − 0.0699 and CumCRP ≥ 3 mg/L

CumAIP ≥ − 0.0699 and CumCRP < 1 mg/L

CumAIP ≥ − 0.0699 and 1 ≤ CumCRP < 3 mg/L

CumAIP ≥ − 0.0699 and CumCRP ≥ 3 mg/L

 < 45 years (702/10597)

 Incidence rate

3.91

8.68

9.62

11.18

15.16

23.31

 Unadjusted model

Reference

2.22 (1.61,3.05)

2.47 (1.67,3.65)

2.81 (2.06,3.85)

3.82 (2.86,5.09)

5.98 (4.40,8.13)

 Model 1

Reference

1.92 (1.39,2.64)

1.88 (1.27,2.78)

2.00 (1.45,2.76)

2.39 (2.77,3.23)

3.28 (2.36,4.55)

 Model 2

Reference

1.90 (1.38,2.61)

1.83 (1.24,2.72)

1.85 (1.34,2.55)

2.21 (1.64,3.00)

3.02 (2.17,4.20)

  P-INTm: CumAIP median × CumCRP cut-points (1, 3 mg/L) = 0.0439 (Model 2)

45–65 years (2681/26277)

 Incidence rate

8.27

14.01

16.44

18.23

26.03

27.77

 Unadjusted model

Reference

1.69 (1.43,1.99)

1.95 (1.64,2.33)

2.19 (1.85,2.58)

3.12 (2.69,3.62)

3.32 (2.84,3.87)

 Model 1

Reference

1.53 (1.30,1.81)

1.69 (1.42,2.03)

1.90 (1.61,2.25)

2.46 (2.12,2.86)

2.47 (2.10,2.90)

 Model 2

Reference

1.51 (1.29,1.78)

1.69 (1.42,2.03)

1.83 (1.55,2.17)

2.36 (2.03,2.75)

2.39 (2.03,2.81)

  P-INTm: CumAIP median × CumCRP cut-points (1, 3 mg/L) = 0.0710 (Model 2)

 > 65 years (504/6051)

 Incidence rate

8.66

16.82

12.48

22.40

26.91

31.12

 Unadjusted model

Reference

1.94 (1.35,2.78)

1.41 (0.96,2.08)

2.56 (1.72,3.80)

3.06 (2.17,4.33)

3.53 (2.49,5.00)

 Model 1

Reference

1.80 (1.25,2.58)

1.28 (0.87,1.88)

2.20 (1.47,3.27)

2.45 (1.73,2.49)

2.71 (1.90,3.87)

 Model 2

Reference

1.76 (1.22,2.53)

1.24 (0.84,1.83)

2.10 (1.41,3.13)

2.37 (1.66,3.37)

2.62 (1.83,3.75)

  P-INTm: CumAIP median × CumCRP cut-points (1, 3 mg/L) = 0.0300 (Model 2)

  1. P-INTm: co-exposure subgroups*age subgroups (< 45, 45 ~ 65, ≥ 65 years) = 0.0743 (model 2)
  2. Model 1: adjusted for age, sex, education, smoking status, drinking status, physical exercise, family history of diabetes, BMI, antihypertensives (yes or no), and lipid-lowering agents (yes or no);
  3. Model 2: model 1 + TC, hypertension degree, and eGFR
  4. CumAIP cumulative atherogenic index of plasma, CumCRP cumulative high-sensitivity C-reactive protein, CI confidence interval, eGFR estimated glomerular filtration rate, HR hazard ratio, TC total cholesterol, INTm multiplicative interaction
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Cardiovascular Diabetology

ISSN: 1475-2840