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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems

Fig. 5

ncRNA transfer between immune and cardiovascular cells. Early endosome in immune cells matures into late endosome, internalizing ncRNAs in the process. Depending on their pH and molecular content, late endosomes can further mature either into lysosomes or into multivesicular bodies. Multivesicular bodies then fuse with the plasma membrane releasing their EVs content in the extracellular milieu. EVs are subsequently internalized by target cardiovascular cells through either receptor-mediated endocytosis or membrane fusion, releasing their cargo in the cytoplasm of target cells. Cardiovascular cells can in turn signal back to target immune cells releasing their EVs. EV: extracellular vesicle, MVB: multivescicular body, sEV: small extracellular vesicle. Figure created with BioRender.com online tool

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Cardiovascular Diabetology

ISSN: 1475-2840