Table 4 Comorbidity
| Â | Meta-analysis | DPV/DIVE patients with CKDa | ||||
|---|---|---|---|---|---|---|
|  | FIDELITY | Total | Total ACEi/ARB | RCT ( +) | RCT (-) | p-value |
|  | n = 13,026 | n = 65,168 | n = 28,359 | n = 12,322 | n = 16,037 | RCT + vs. - |
Arterial hypertension, n (%) | 96.5 | 78.0 (140/90) | 100.0 | 100.0 | 100.0 | 1.0 |
Diabetic retinopathy, n (%) | 38.0 | 6.0 | 7.5 | 7.5 | 7.5 | 0.9981 |
Diabetic neuropathy, n (%) | 26.9 | 45.9 | 50.5 | 53.7 | 48.0 |  < 0.0001 |
Lipid metabolism disorders, n (%) | 45.6 | 87.4 | 91.6 | 92.0 | 91.2 | 0.0320 |
History of CV disease, n (%) | Â | Â | Â | Â | Â | Â |
 Coronary artery disease w/o MI, n (%) | 30.7 | 11.0 | 13.9 | 13.2 | 14.5 |  < 0.0001 |
 Peripheral arterial disease, n (%) | 16.0 | 23.8 | 27.2 | 27.5 | 27.0 | 0.3972 |
 Myocardial infarction, n (%) | 15.5 | 10.2 | 13.0 | 12.3 | 13.5 | 0.0048 |
 Ischemic stroke, n (%) | 11.9 | 9.0 | 11.7 | 11.6 | 11.7 | 0.8986 |
 Heart failure, n (%) | 7.5 | 12.3 | 16.6 | 15.3 | 17.7 |  < 0.0001 |