Table 3 General patient characteristics
| Â | Meta-analysis | DPV/DIVE patients with CKDa | ||||
|---|---|---|---|---|---|---|
|  | FIDELITY | Total | Total ACEi/ARB | RCT ( +) | RCT (-) | p-value |
|  | n = 13,026 | n = 65,168 | n = 28,359 | n = 12,322 | n = 16,037 | RCT + vs. - |
Age, years, mean ± SD | 64.8 ± 9.5 | 72.6 ± 12.1 | 73.4 ± 11.3 | 72.9 ± 10.6 | 73.7 ± 11.9 |  < 0.0001 |
Gender, male, % | 69.8 | 52.6 | 52.6 | 57.2 | 49.1 |  < 0.0001 |
BMI, kg/m2, mean ± SD | 31.3 ± 6.0 | 31.2 ± 6.9 | 31.5 ± 6.8 | 31.5 ± 6.7 | 31.5 ± 6.9 | 0.7183 |
Duration of diabetes, years, mean ± SD | 15.4 ± 8.7 | 13.7 ± 10.0 | 13.9 ± 9.9 | 13.8 ± 9.9 | 14.0 ± 9.9 | 0.0423 |
Systolic blood pressure, mmHg, mean ± SD | 136.7 ± 14.2 | 135.3 ± 18.7 | 136.6 ± 19.1 | 138.7 ± 19.2 | 135.0 ± 18.8 |  < 0.0001 |
Diastolic blood pressure, mmHg, mean ± SD | 76.4 ± 9.6 | 75.8 ± 10.8 | 76.0 ± 11.0 | 77.0 ± 11.0 | 75.3 ± 10.9 |  < 0.0001 |
eGFR (CKD-EPI), mL/min/1.73 m2, mean ± SD | 57.6 ± 21.7 | 54.2 ± 25.1 | 53.7 ± 24.0 | 60.1 ± 19.5 | 48.6 ± 26.0 |  < 0.0001 |
  ≥ 60, % | 39.9 | 31.3 | 30.8 | 49.8 | 15.8 |  < 0.0001 |
 45 to < 60, % | 26.4 | 29.1 | 29.6 | 23.4 | 34.5 |  < 0.0001 |
 25 to < 45, % | 32.5 | 29.1 | 29.9 | 26.9 | 32.3 |  < 0.0001 |
  < 25, % | 1.2 | 12.7 | 11.3 | 0.0 | 20.0 |  < 0.0001 |
UACR, mg/g | Â | Â | Â | Â | Â | Â |
  < 30, % | 1.8 | 43.2 | 41.5 | 0.0 | 73.4 |  < 0.0001 |
 30 to < 300, % | 31.5 | 43.4 | 43.9 | 75.1 | 19.9 |  < 0.0001 |
  ≥ 300, % | 66.7 | 13.4 | 14.6 | 24.9 | 6.7 |  < 0.0001 |
Serum potassium, mEq/L, mean ± SD | 4.35 ± 0.44 | 4.39 ± 0.66b | 4.41 ± 0.66c | 4.4 ± 0.6 | 4.5 ± 0.7 |  < 0.0001 |
HbA1c, %, mean (SD) | 7.7 ± 1.4 | 7.6 ± 1.9 | 7.6 ± 1.9 | 7.7 ± 1.9 | 7.6 ± 1.8 |  < 0.0001 |