The degree of cortisol secretion is associated with diabetes mellitus and hypertension in patients with nonfunctioning adrenal tumors

Table 1 Association between cortisol after dexamethasone suppression test (F-1mgDST) levels and the presence of hypertension, diabetes mellitus, obesity, dyslipidaemia, and cardiovascular events by receiver operating characteristic (ROC) curve

	F-1mgDST (AUC)	p value	95% IC		Youden’s Index
	F-1mgDST (AUC)	p value	Lower limit	Upper limit	Cut-off (µg/dL)	Sensitivity (%)	1-Specificity (%)
Hypertension	0.588	p < 0.001	0.543	0.633	1.18	60.5	45.5
Diabetes mellitus	0.610	p < 0.001	0.554	0.665	1.18	66.6	49.1
Hypertension plus diabetes mellitus	0.611	p = 0.001	0.546	0.675	1.19	60.4	49.6
Obesity	0.507	p = 0.767	0.459	0.556
Dyslipidaemia	0.494	p = 0.826	0.445	0.544
Cardiovascular Events**	0.587	p = 0.121	0.484	0.690

F-1mgDST: cortisol after 1 mg overnight dexamethasone suppression test; AUC: area under the curve; IC: interval of confidence
^*Data on cardiovascular events (i.e.: myocardial infarction, stroke, transient ischemic attack, angina pectoris, pulmonary embolism, intracerebral hemorrhage, peripheral artery disease) have been obtained from a subgroup of 314 patients
For cortisol multiply × 27.56 to convert from μg/dL to nmol/L. The statistically significant associations are reported in bold

ISSN: 1475-2840