Characteristics | Control (n = 50) | HFpEF without T2DM (n = 48) | HFpEF with T2DM (n = 51) | P-value |
---|---|---|---|---|
Epicardial adipose tissue thickness (mm) | 5.1 (IQR, 4.3–6.8) | 7.9 (IQR, 7.4–8.3)* | 8.8 (IQR, 8.6–8.9)*, † | < 0.001 |
Interventricular septal thickness at end diastole (mm) | 7.5 (IQR, 6.6–8.2) | 10.2 (IQR, 9.3–10.6)* | 9.8 (IQR, 9.3–10.8)* | < 0.001 |
Posterior wall thickness at end diastole (mm) | 7.6 (IQR, 6.6–8.3) | 10.2 (IQR, 9.4–10.6)* | 9.9 (IQR, 9.3–10.7)* | < 0.001 |
Left ventricular end-diastolic diameter (mm) | 46.5 ± 1.8 | 45.8 ± 2.5 | 46.1 ± 2.6 | 0.304 |
Left ventricular end-systolic diameter (mm) | 27.0 (IQR, 26.1–28.3) | 29.5 (IQR, 28.0–31.4)* | 28.5 (IQR, 26.9–30.6)* | < 0.001 |
Left ventricular end-diastolic volume index (mL/m2) | 57.4 ± 5.9 | 55.5 ± 7.5 | 57.4 ± 8.4 | 0.321 |
Left ventricular end-systolic volume index (mL/m2) | 15.4 (IQR, 13.7–17.9) | 19.6 (IQR, 16.6–22.5)* | 18.5 (IQR, 16.2–22.2)* | < 0.001 |
Left ventricular ejection fraction (%) | 74 (IQR, 67–77) | 64 (IQR, 59–69)* | 66 (IQR, 62–72)* | < 0.001 |
Left atrial ejection fraction (%) | 58 (IQR, 57–61) | 48 (IQR, 45–52)* | 44 (IQR, 42–48)*, † | < 0.001 |
SI (mL/m2) | 41.3 ± 6.3 | 35.7 ± 6.6* | 38.4 ± 7.8 | < 0.001 |
CI (L/min/m2) | 2.9 ± 0.5 | 2.5 ± 0.5* | 2.6 ± 0.6* | < 0.001 |
Left ventricular mass index (g/m2) | 79 (IQR, 70–90) | 116 (IQR, 104–125)* | 119 (IQR, 102–130)* | < 0.001 |
Left atrial volume index (mL/m2) | 29 (IQR, 28–30) | 36 (IQR, 35–40)* | 35 (IQR, 33–38)* | < 0.001 |
Relative wall thickness | 0.32 (IQR, 0.29–0.36) | 0.44 (IQR, 0.42–0.47)* | 0.43 (IQR, 0.41–0.47)* | < 0.001 |
E (cm/s) | 89.4 (IQR, 80.1–91.4) | 57.6 (IQR, 51.9–62.8)* | 59.8 (IQR, 53.1–66.4)* | < 0.001 |
A (cm/sec) | 83.9 (IQR, 80.0–89.2) | 77.9 (IQR, 70.0–82.0)* | 79.2 (IQR, 69.6–88.2)* | < 0.001 |
E/A | 1.02 (IQR, 1.00–1.06) | 0.79 (IQR, 0.71–0.86)* | 0.81 (IQR, 0.70–0.93)* | < 0.001 |
DcT (cm/s) | 195 (IQR, 186–218) | 238 (IQR, 224–268)* | 229 (IQR, 218–249)* | < 0.001 |
Lateral e′ (cm/s) | 10.9 (IQR, 10.7–11.2) | 5.2 (IQR, 3.9–6.2)* | 5.4 (IQR, 4.3–6.1)* | < 0.001 |
Medial e′ (cm/s) | 8.7 (IQR, 6.7–10.0) | 2.8 (IQR, 2.4–3.6)* | 2.8 (IQR, 2.5–3.7)* | < 0.001 |
Mean e′ (cm/s) | 9.7 (IQR, 8.7–10.4) | 3.9 (IQR, 3.2–4.9)* | 4.1 (IQR, 3.4–5.0)* | < 0.001 |
E/e′ (cm/s) | 9.0 (IQR, 8.3–9.6) | 14.6 (IQR, 13.2–16.6)* | 14.7 (IQR, 13.7–16.0)* | < 0.001 |
Peak tricuspid regurgitation velocity (m/s) | 2.2 (IQR, 2.1–2.3) | 2.9 (IQR, 2.6–3.1)* | 2.9 (IQR, 2.8–3.0)* | < 0.001 |
Left ventricular global longitudinal strain (%) | −22.0 (IQR, −18.9– −23.2) | −15.0 (IQR, −16.4– −14.3)* | −14.9 (IQR, −16.1– −13.9)* | < 0.001 |
Left atrial global longitudinal strain (%) | 35.0 (IQR, 32.8–38.8) | 31.9 (IQR, 30.5–33.8)* | 27.6 (IQR, 25.5–30.5)*, † | < 0.001 |
Mitral regurgitation | ||||
Mitral regurgitation volume (mL) | – | 30.6 (IQR, 12.3–31.4) | 30.5 (IQR, 16.4–31.3) | 0.807 |
Effective regurgitant orifice area (cm2) | – | 0.23 (IQR, 0.10–0.24) | 0.22 (IQR, 0.14–0.27) | 0.272 |
Mild (%) | – | 21 | 25 | 0.583 |
Moderate (%) | – | 25 | 29 | 0.622 |
Estimated pulmonary artery systolic pressure (mmHg) | 29.3 (IQR, 27.4–32.6) | 43.1 (IQR, 40.4–48.4)* | 42.0 (IQR, 37.5–48.2)* | < 0.001 |
Presence of concentric remodeling (%) | 0 | 77* | 75* | < 0.001 |
Presence of eccentric hypertrophy (%) | 0 | 73* | 82* | < 0.001 |
Presence of concentric hypertrophy (%) | 0 | 50* | 57* | < 0.001 |