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Table 2 Echocardiography data of all the groups

From: Association of complication of type 2 diabetes mellitus with hemodynamics and exercise capacity in patients with heart failure with preserved ejection fraction: a case–control study in individuals aged 65–80 years

Characteristics

Control (n = 50)

HFpEF without T2DM (n = 48)

HFpEF with T2DM (n = 51)

P-value

Epicardial adipose tissue thickness (mm)

5.1 (IQR, 4.3–6.8)

7.9 (IQR, 7.4–8.3)*

8.8 (IQR, 8.6–8.9)*, †

 < 0.001

Interventricular septal thickness at end diastole (mm)

7.5 (IQR, 6.6–8.2)

10.2 (IQR, 9.3–10.6)*

9.8 (IQR, 9.3–10.8)*

 < 0.001

Posterior wall thickness at end diastole (mm)

7.6 (IQR, 6.6–8.3)

10.2 (IQR, 9.4–10.6)*

9.9 (IQR, 9.3–10.7)*

 < 0.001

Left ventricular end-diastolic diameter (mm)

46.5 ± 1.8

45.8 ± 2.5

46.1 ± 2.6

0.304

Left ventricular end-systolic diameter (mm)

27.0 (IQR, 26.1–28.3)

29.5 (IQR, 28.0–31.4)*

28.5 (IQR, 26.9–30.6)*

 < 0.001

Left ventricular end-diastolic volume index (mL/m2)

57.4 ± 5.9

55.5 ± 7.5

57.4 ± 8.4

0.321

Left ventricular end-systolic volume index (mL/m2)

15.4 (IQR, 13.7–17.9)

19.6 (IQR, 16.6–22.5)*

18.5 (IQR, 16.2–22.2)*

 < 0.001

Left ventricular ejection fraction (%)

74 (IQR, 67–77)

64 (IQR, 59–69)*

66 (IQR, 62–72)*

 < 0.001

Left atrial ejection fraction (%)

58 (IQR, 57–61)

48 (IQR, 45–52)*

44 (IQR, 42–48)*, †

 < 0.001

SI (mL/m2)

41.3 ± 6.3

35.7 ± 6.6*

38.4 ± 7.8

 < 0.001

CI (L/min/m2)

2.9 ± 0.5

2.5 ± 0.5*

2.6 ± 0.6*

 < 0.001

Left ventricular mass index (g/m2)

79 (IQR, 70–90)

116 (IQR, 104–125)*

119 (IQR, 102–130)*

 < 0.001

Left atrial volume index (mL/m2)

29 (IQR, 28–30)

36 (IQR, 35–40)*

35 (IQR, 33–38)*

 < 0.001

Relative wall thickness

0.32 (IQR, 0.29–0.36)

0.44 (IQR, 0.42–0.47)*

0.43 (IQR, 0.41–0.47)*

 < 0.001

E (cm/s)

89.4 (IQR, 80.1–91.4)

57.6 (IQR, 51.9–62.8)*

59.8 (IQR, 53.1–66.4)*

 < 0.001

A (cm/sec)

83.9 (IQR, 80.0–89.2)

77.9 (IQR, 70.0–82.0)*

79.2 (IQR, 69.6–88.2)*

 < 0.001

E/A

1.02 (IQR, 1.00–1.06)

0.79 (IQR, 0.71–0.86)*

0.81 (IQR, 0.70–0.93)*

 < 0.001

DcT (cm/s)

195 (IQR, 186–218)

238 (IQR, 224–268)*

229 (IQR, 218–249)*

 < 0.001

Lateral e′ (cm/s)

10.9 (IQR, 10.7–11.2)

5.2 (IQR, 3.9–6.2)*

5.4 (IQR, 4.3–6.1)*

 < 0.001

Medial e′ (cm/s)

8.7 (IQR, 6.7–10.0)

2.8 (IQR, 2.4–3.6)*

2.8 (IQR, 2.5–3.7)*

 < 0.001

Mean e′ (cm/s)

9.7 (IQR, 8.7–10.4)

3.9 (IQR, 3.2–4.9)*

4.1 (IQR, 3.4–5.0)*

 < 0.001

E/e′ (cm/s)

9.0 (IQR, 8.3–9.6)

14.6 (IQR, 13.2–16.6)*

14.7 (IQR, 13.7–16.0)*

 < 0.001

Peak tricuspid regurgitation velocity (m/s)

2.2 (IQR, 2.1–2.3)

2.9 (IQR, 2.6–3.1)*

2.9 (IQR, 2.8–3.0)*

 < 0.001

Left ventricular global longitudinal strain (%)

−22.0 (IQR, −18.9– −23.2)

−15.0 (IQR, −16.4– −14.3)*

−14.9 (IQR, −16.1– −13.9)*

 < 0.001

Left atrial global longitudinal strain (%)

35.0 (IQR, 32.8–38.8)

31.9 (IQR, 30.5–33.8)*

27.6 (IQR, 25.5–30.5)*, †

 < 0.001

Mitral regurgitation

 Mitral regurgitation volume (mL)

30.6 (IQR, 12.3–31.4)

30.5 (IQR, 16.4–31.3)

0.807

 Effective regurgitant orifice area (cm2)

0.23 (IQR, 0.10–0.24)

0.22 (IQR, 0.14–0.27)

0.272

 Mild (%)

21

25

0.583

 Moderate (%)

25

29

0.622

 Estimated pulmonary artery systolic pressure (mmHg)

29.3 (IQR, 27.4–32.6)

43.1 (IQR, 40.4–48.4)*

42.0 (IQR, 37.5–48.2)*

 < 0.001

 Presence of concentric remodeling (%)

0

77*

75*

 < 0.001

 Presence of eccentric hypertrophy (%)

0

73*

82*

 < 0.001

 Presence of concentric hypertrophy (%)

0

50*

57*

 < 0.001

  1. Normal distribution data are expressed as means ± standard deviations, non-normal distribution data are expressed as medians, and nominal variables are expressed as percentages.
  2. HFpEF heart failure with preserved ejection fraction, IQR interquartile range, SI stroke volume index, CI cardiac output index, E peak early flow velocity, A Late diastolic flow velocity, E/A ratio of peak early and late diastolic flow velocities, DcT deceleration time, e′ peak early diastolic tissue velocity, E/e' ratio of the mitral inflow early diastolic velocity to the mean e′ velocity from the septal and lateral sides of the mitral annulus
  3. *P < 0.05 vs the Control group
  4. P < 0.05 vs the HFpEF-without-T2DM group