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Fig. 7 | Cardiovascular Diabetology

Fig. 7

From: Diabetes is accompanied by secretion of pro-atherosclerotic exosomes from vascular smooth muscle cells

Fig. 7

Exposure of CD14 + monocytes to DVEs promotes M1 macrophage polarization in a miR-221/222 dependent manner. A M1:M2 score for macrophages treated with vehicle (Ctrl), NVEs, the M2 phenotype inducer, IL-4, DVEs, and the M2 phenotype inducer, interferon-γ. B M1:M2 score for macrophages treated with vehicle (Ctrl), NVEs, NVE+KDs, DVEs, and DVE+KDs. C IL-6 concentrations in conditioned media of CD14 + macrophages treated with vehicle (Ctrl), NVEs, NVE+KDs, DVEs, and DVE+KDs. D QKI copies in CD14 + macrophages treated with vehicle (Ctrl), NVEs, NVE+Ds, DVEs, and DVE+KDs. E QKI copies in CD14 + macrophages treated with vehicle (Ctrl), NVEs, NVE+KDs, DVEs, and DVE+KDs. F M1:M2 score for macrophages treated with non-targeting (Ctrl) or QKI targeting siRNA.*p < 0.05

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Cardiovascular Diabetology

ISSN: 1475-2840