Fig. 2

AR inhibition by AT-001 mitigates DbCM. (a–i) Representative images of tissue Doppler (a), tissue Doppler e’/a’ ratio (b), E/e’ ratio (c), representative M-mode images (d), % left ventricular ejection fraction (LVEF) (e), % left ventricular fractional shortening (LVFS) (f), stroke volume (g), cardiac output (h), and LV mass corrected (i) assessed by ultrasound echocardiography in C57BL/6J mice with experimental DbCM (n = 7) at 3 weeks post-treatment with either vehicle control (VC) or AT-001 (40 mg/kg/day). Values represent means ± SEM. Differences were determined using an unpaired two-tailed Student’s t-test. *P < 0.05 significantly different from vehicle control-treated mice