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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Combining glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) in patients with type 2 diabetes mellitus (T2DM)

Fig. 1

Complementary mechanisms of action of sodium-glucose cotransporter-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs). HHF, hospitalization for heart failure; MACE, major adverse cardiovascular events. SGLT2is improve insulin secretion without increasing insulin levels. The black dotted line indicates that there is insufficient clinical evidence to support the beneficial effects of GLP-1RAs on renal impairment [87]

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Cardiovascular Diabetology

ISSN: 1475-2840