Table 4 Hazard ratios (HR) and 95% Confidence intervals of uACR for heart failure (subgroup analysis)
No. | Incident heart failure (%) | Incidence rate (/1000 person-years) | < 3 mg/mmol | 3–30 mg/mmol | ≥ 30 mg/mmol | Interaction p value | |
|---|---|---|---|---|---|---|---|
Gender | 0.054 | ||||||
Male | 6754 | 146 | 4.45 | Ref. | 2.50 (1.65, 3.77) | 7.79 (4.91, 12.36) | |
Female | 2533 | 70 | 5.60 | Ref. | 1.70 (1.00, 2.93) | 3.54 (1.73, 7.25) | |
Baseline eGFR | 0.022 | ||||||
≥ 90 | 3456 | 61 | 3.92 | Ref. | 2.59 (1.49, 4.50) | 2.21 (1.01, 6.04) | |
60–90 | 4694 | 97 | 5.37 | Ref. | 1.84 (1.14, 2.96) | 5.19 (2.94, 9.16) | |
< 60 | 1137 | 58 | 14.51 | Ref. | 2.74 (1.21, 6.20) | 15.74 (7.21, 34.36) | |
Baseline SBP | 0.652 | ||||||
SBP < 140 | 3582 | 64 | 4.41 | Ref. | 2.01 (1.18, 3.61) | 2.78 (1.25, 6.19) | |
140 ≤ SBP < 160 | 3424 | 75 | 5.59 | Ref. | 2.49 (1.42, 4.39) | 10.37 (5.62, 19.15) | |
SBP ≥ 160 | 2281 | 77 | 8.30 | Ref. | 2.14 (1.19, 3.84) | 5.81 (3.06, 11.04) | |
Baseline HbA1c | 0.186 | ||||||
HbA1c < 7.0%(53.01 mmol/mol) | 3857 | 62 | 4.41 | Ref. | 3.65 (1.99, 6.68) | 13.99 (6.96, 28.16) | |
HbA1c ≥ 7.0%(53.01 mmol/mol) | 5430 | 154 | 6.76 | Ref. | 1.78 (1.21, 2.62) | 4.47 (2.87, 6.97) |