Epicardial adipose tissue density is a better predictor of cardiometabolic risk in HFpEF patients: a prospective cohort study

Liu, Jie; Yu, Qi; Li, Ziyang; Zhou, Yujiao; Liu, Zhiqiang; You, Linna; Tao, Li; Dong, Qian; Zuo, Ziyu; Gao, Lei; Zhang, Dongying

doi:10.1186/s12933-023-01778-8

Cardiovascular Diabetology

Table 4 Multivariable linear regression of EAT density and volume with cardiometabolic risk markers

From: Epicardial adipose tissue density is a better predictor of cardiometabolic risk in HFpEF patients: a prospective cohort study

		EAT density		EAT volume
		β (95% CI)	p value	β (95% CI)	p value
BMI	age, gender	− 0.14 (− 0.21, − 0.08)	< 0.001
	+ BMI	–	–
	+ EAT volume	− 0.08 (− 0.15, − 0.01)	0.018	0.03 (0.01, 0.04)	< 0.001
WC	age, gender	− 0.34 (− 0.55, − 0.12)	0.002
	+ BMI	− 0.11 (− 0.25, 0.03)	0.118
	+ EAT volume	− 0.25 (− 0.47, − 0.03)	0.027	0.06 (0.01, 0.10)	0.014
Non-HDL-C	age, gender	− 0.02 (− 0.04,0)	0.022
	+ BMI	− 0.02 (− 0.04,0)	0.037
	+ EAT volume	− 0.02 (− 0.04,0)	0.042	0 (0,0)	0.861
TG	age, gender	− 0.03 (− 0.04, − 0.01)	< 0.001
	+ BMI	− 0.03 (− 0.04, − 0.01)	0.001
	+ EAT volume	− 0.03 (− 0.04, − 0.01)	0.002	0 (0, 0)	0.623
FPG	age, gender	− 0.05 (− 0.08, − 0.02)	0.002
	+ BMI	− 0.05 (− 0.08, − 0.01)	0.007
	+ EAT volume	− 0.05 (− 0.09, − 0.02)	0.005	0 (− 0.01, 0.01)	0.697
TyG	age, gender	− 0.03 (− 0.04, − 0.02)	< 0.001
	+ BMI	− 0.02 (− 0.03, − 0.01)	< 0.001
	+ EAT volume	− 0.03 (− 0.04, − 0.01)	< 0.001	0 (0, 0)	0.931
Log₂(TG/HDL-C)	age, gender	− 0.03 (− 0.05, − 0.02)	< 0.001
	+ BMI	− 0.03 (− 0.05, − 0.02)	< 0.001
	+ EAT volume	− 0.03 (− 0.05, − 0.01)	0.001	0 (0, 0.01)	0.202
METS-IR	age, gender	− 0.36 (− 0.49, − 0.23)	< 0.001
	+ BMI	− 0.11 (− 0.18, − 0.04)	0.004
	+ EAT volume	− 0.21 (− 0.36, − 0.07)	0.004	0.05 (0.03, 0.07)	< 0.001
MetS Z-score	age, gender	− 0.04 (− 0.06, − 0.02)	< 0.001
	+ BMI	− 0.03 (− 0.04, − 0.01)	0.009
	+ EAT volume	− 0.03 (− 0.05, − 0.01)	0.002	0 (0, 0.01)	0.365
Log₂(CACS + 1)	age, gender	− 0.09(− 0.15, − 0.02)	0.008
	+ BMI	− 0.11 (− 0.18, − 0.04)	0.002
	+ EAT volume	− 0.09 (− 0.16, − 0.02)	0.012	0 (-0.01, 0.01)	0.855

Non-HDL-C was calculated as total cholesterol minus high-density lipoprotein cholesterol
BMI body mass index, CACS coronary artery calcium score, CI confidence interval, EAT epicardial adipose tissue, FPG fasting plasma glucose, MetS Z-score metabolic syndrome severity Z score, METS‐IR metabolic score for insulin resistance, SD standard deviation, TG triglyceride, TyG triglyceride and glucose index, WC waist circumference

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ISSN: 1475-2840

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