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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Maternal obesity and gestational diabetes reprogram the methylome of offspring beyond birth by inducing epigenetic signatures in metabolic and developmental pathways

Fig. 3

Obesity-mediated maternal influence during pregnancy alters the methylome of offspring during the first year of life. a Barplots depicting the number of hyper- and hypomethylated DMPs (FDR < 0.05) found in the Ob.C, ObDia.C and ObDia.Ob cross-sectional comparisons. b Venn diagram showing the intersection between hyper- and hypomethylated DMPs found in the Ob.C, ObDia.C and ObDia.Ob cross-sectional comparisons. c Barplots depicting the number of hyper- and hypomethylated DMRs (FDR < 0.05) found in the Ob.C, ObDia.C and ObDia.Ob cross-sectional comparisons. d Venn Diagram showing the intersection between hyper- and hypomethylated CpGs from DMRs found in the Ob.C, ObDia.C and ObDia.Ob cross-sectional comparisons. e Barplots depicting the relative distribution of hyper- and hypomethylated DMRs from the Ob.C, ObDia.C and ObDia.Ob comparisons according to their CpG island locations status. F Barplots showing the relative distribution of hyper- and hypomethylated DMRs from the Ob.C, ObDia.C and ObDia.Ob comparisons according to their gene location status. Rightmost bars represent the background distribution considering all 772,088 probes analysed. g On the left, scatter plot showing the PCA of the subjects according to their methylation values at Ob.C, ObDia.C, ObDia.Ob DMPs. On the right, scatter plot representing the PCA of the subjects according to their methylation values at CpGs from Ob.C, ObDia.C, ObDia.Ob DMRs

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Cardiovascular Diabetology

ISSN: 1475-2840