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Table 2 Number of events, incidence rates, and adjusted HRs for cardiovascular outcomes across the spectrum of diabetes status or NT-proBNP categories

From: The joint association of diabetes status and NT-ProBNP with adverse cardiac outcomes in patients with non-ST-segment elevation acute coronary syndrome: a prospective cohort study

 

Events/population

Incidence rate per 1000 person‑years (95% CI)

Adjusted HR (95% CI) *

MACCEs

   

 Diabetes status

   

  Normoglycemia

188/1848

38.7 (33.6–44.7)

Ref.

  Prediabetes

289/2360

48.7 (43.4–54.7)

1.15 (0.95–1.39)

  Diabetes

593/3748

62.6 (57.8–67.9)

1.42 (1.20–1.68)

 NT-proBNP tertiles

   

  T1 < 92 pg/ml

181/2653

27.8 (24.0–32.1)

Ref.

  T2 92–335 pg/ml

290/2655

41.8 (37.2–46.9)

1.24 (1.02–1.50)

  T3 ≥ 336 pg/ml

599/2648

88.2 (81.4–95.5)

1.72 (1.40–2.11)

All-cause mortality

 Diabetes status

   

  Normoglycemia

79/1848

15.5 (12.4–19.3)

Ref.

  Prediabetes

119/2360

18.9 (15.8–22.6)

1.00 (0.75–1.34)

  Diabetes

263/3748

25.7 (22.8–29.0)

1.37 (1.05–1.78)

 NT-proBNP tertiles

   

  T1 < 92 pg/ml

34/2653

5.0 (3.6–7.0)

Ref.

  T2 92–335 pg/ml

87/2655

11.8 (9.6–14.6)

1.47 (0.98–2.21)

  T3 ≥ 336 pg/ml

340/2648

45.7 (41.1–50.8)

2.80 (1.89–4.17)

  1. *Covariates included in the model were age, sex, BMI, NSTE-ACS status, previous hypertension, previous dyslipidemia, previous myocardial infarction, systolic blood pressure, heart rate, LVEF, eGFR, hs-CRP, LDL-C, smoking status, and in-hospital treatments (PCI, antiplatelet therapy, β-blocker, ACEI or ARB, and statins); Statistically significant estimates in bold
  2. Abbreviations see Table 1