Table 1 Baseline characteristics of the REWIND placebo group used as additional risk factors to adjust for obesity measures
|  | Placebo group (N = 4952) |
|---|---|
Age (years) | 66.2 (6.5) |
Female | 2283 (46.1) |
Race | |
 American Indian or Alaska Native | 543 (11.0) |
 Asian | 218 (4.4) |
 Black or African American | 346 (7.0) |
 Native Hawaiian or other Pacific Islander | 22 (0.4) |
 White | 3744 (75.6) |
BMI (kg/m2) | 32.3 (5.8) |
BMI categories (kg/m2) | |
 Normal (< 25 kg/m2) | 355 (7.2) |
 Overweight (25- < 30 kg/m2) | 1566 (31.6) |
 Class I (30- < 35 kg/m2) | 1640 (33.1) |
 Class II-III (≥ 35 kg/m2) | 1391 (28.1) |
Waist circumference (cm) | |
 Female | 106.6 (13.0) |
 Male | 110.8 (13.4) |
Hip circumference (cm) | |
 Female | 113.0 (13.6) |
 Male | 108.5 (11.4) |
Waist-to-hip ratio | |
 Female | 0.95 (0.07) |
 Male | 1.02 (0.07) |
Baseline HbA1c (%) | 7.4% (1.1) |
Baseline eGFR (mL/min/1.73 m2) | |
 < 30 | 55 (1.1) |
 30–59 | 1063 (21.5) |
 60–89 | 2469 (49.9) |
 ≥ 90 | 1238 (25.0) |
Prior CVDa | 1554 (31.4) |
History of myocardial infarction | 798 (16.1) |
History of myocardial ischemia by a stress test or with cardiac imaging | 447 (9.0) |
Ischemic stroke | 253 (5.1) |
Coronary, carotid or peripheral artery revascularization | 886 (17.9) |
Unstable angina | 306 (6.2) |
Hospitalization for unstable angina with ECG changes | 590 (11.9) |
Systolic blood pressure (mm Hg) | 137.3 (17.0) |
Diastolic blood pressure (mm Hg) | 78.5 (9.9) |
UACR (mg/mmol) | 1.9 (0.70–7.38) |
Total cholesterol (mmol/L) | 4.5 (1.16) |
LDL cholesterol (mmol/L) | 2.6 (0.98) |
HDL cholesterol (mmol/L) | 1.2 (0.36) |
Non-HDL cholesterol (mmol/L) | 3.3 (1.11) |
Triglycerides (mmol/L) | 1.60 (1.20–2.25) |
Current tobacco usage | 713 (14.4) |
Past tobacco usage | 2409 (48.6) |
Current alcohol consumption | 1736 (35.1) |
Antihypertensive agents | 4654 (94.0) |
Lipid lowering agents | 3485 (70.4) |
Anticoagulant agents | 2557 (51.6) |
Antithrombotic agents | 2909 (58.7) |