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Table 2 Comparisons of CMR derived LV function and LV global strains findings among controls, T2DM patients without anemia and T2DM patients with anemia groups

From: The worsening effect of anemia on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T CMR feature tracking study

 

Controls (n = 67)

T2DM without anemia (n = 174)

T2DM with anemia (n = 62)

P value

LV function parameters

 LVEDVI, mL

78.9 ± 13.7

80.7 ± 22.4

92.7 ± 30.9*§

0.001

 LVESVI, mL

30.3 (23.8, 36.1)

30.6 (25.4, 40.3)

38.5 (27.4, 57.9)*§

0.000

 LVSVI, mL

48.4 ± 9.0

44.3 ± 10.4*

46.9 ± 14.3

0.025

 LVEF, %

61.6 ± 7.8

55.6 ± 11.2*

51.9 ± 12.0*

0.000

 LVMI, g

43.7 ± 9.0

48.8 ± 15.2*

55.5 ± 17.4*§

0.000

 LV concentricity index, g/mL

0.55 (0.48, 0.63)

0.59 (0.51, 0.70)

0.60 (0.48, 0.70)

0.096

Peak strain (%)

 Radial

33.4 (29.0, 42.4)

31.2 (23.6, 36.7)*

23.2 (16.2, 36.4)*§

0.000

 Circumferential

−21.1 ± 3.0

−18.8 ± 4.3*

−15.6 ± 5.3*§

0.000

 Longitudinal

−13.2 ± 2.5

−11.5 ± 4.3*

−8.9 ± 4.4*§

0.000

PSSR (1/s)

 Radial

1.9 (1.5, 2.7)

1.7 (1.2, 2.1)*

1.5 (0.9, 2.2)*

0.007

 Circumferential

−1.0 (−1.2, −0.9)

−1.0 (−1.1, −0.8)*

−0.9 (−1.1, −0.7)*

0.001

 Longitudinal

−0.7 (−0.8, −0.6)

−0.7 (−0.8, −0.5)*

−0.6 (−0.7, −0.4)

0.024

PDSR(1/s)

 Radial

−2.3 (−2.9, −1.8)

−1.9 (−2.6, −1.4)*

−1.4 (−2.2, −0.9)*§

0.000

 Circumferential

1.2 ± 0.3

1.0 ± 0.4*

0.9 ± 0.3*§

0.000

 Longitudinal

0.8 (0.6, 0.9)

0.7 (0.5, 0.9)

0.5 (0.4, 0.8)*§

0.000

  1. Data are presented as the mean ± SD or median (Q1, Q3)
  2. T2DM type 2 diabetes diabetes mellitus, LV left ventricular, EDV end diastolic volume, ESV end systolic volume, SV stroke volume, EF ejection fraction, M mass, I indexed to BSA, PSSR peak systolic strain rate, PDSR peak diastolic strain rate
  3. “ − ” indicates the direction of strains (negative). Negative strain means shortening, thinning, and/or contraction, while positive strain means lengthening, thickening, and/or relaxation from end-diastole to end-systole
  4. *P less than 0.05 vs. controls
  5. §P less than 0.05 vs. T2DM patients without anemia