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Table 2 Comparison of cardiac magnetic resonance results of LV structure and function in diabetic pigs at different scanning times

From: Early longitudinal changes in left ventricular function and morphology in diabetic pigs: evaluation by 3.0T magnetic resonance imaging

 

Before modelling

2 months after modelling

6 months after modelling

10 months after modelling

16 months after modelling

P value

Geometric and functional

      

 EDV (ml)

32.43 ± 11.67

35.23 ± 10.12

42.08 ± 7.60*

33.45 ± 6.74

27.93 ± 11.49&

0.027

 ESV (ml)

12.87 ± 7.08

14.88 ± 5.92

16.74 ± 11.01

10.33 ± 4.34&

7.96 ± 2.80#&

0.05

 SV (ml)

19.56 ± 6.11

20.35 ± 7.05

25.34 ± 7.93

23.11 ± 4.91

19.97 ± 10.36

0.243

 EF

60.30 ± 10.31

54.05 ± 10.14

56.50 ± 15.82

62.00 ± 9, 67

61.32 ± 13.63

0.250

 HR

98.65 ± 20.57

92.85 ± 19.07

98.04 ± 20.91

96.15 ± 24.56

95.06 ± 24.84

0.963

 CO

2.00 ± 0.67

1.92 ± 0.60

2.76 ± 1.14*#

2.44 ± 0.68

1.86 ± 0.91&

0.046

 LVEDD

29.85 ± 4.47

31.30 ± 6.01

33.72 ± 3.68*

29.57 ± 5.20

25.81 ± 5.66&

0.014

 LVESD

20.58 ± 3.84

21.18 ± 5.86

23.33 ± 6.60

19.52 ± 4.41

15.67 ± 3.47*#&

0.02

 LV wall thickness

9.40 ± 1.94

9.77 ± 1.64

10.25 ± 2.01

10.51 ± 1.94

12.04 ± 1.43*#

0.018

 MM (g)

40.15 ± 10.33

42.41 ± 13.09

51.81 ± 16.18*

52.66 ± 11.16*

54.28 ± 13.24*

0.036

 LVRI (g/ml)

1.36 ± 0.45

1.26 ± 0.57

1.27 ± 0.36

1.52 ± 0.38

2.19 ± 0.97*#&

0.002

Time‒volume curve

      

 PER

104.14 ± 25.26

110.03 ± 34.56

128.90 ± 46.48

125.04 ± 28.20

104.97 ± 47.56

0.323

 PFR

148.50 ± 55.87

136.74 ± 43.36

177.63 ± 79.13

167.18 ± 50.09

138.84 ± 65.46

0.407

 PER/EDV

3.19 ± 0.82

2.93 ± 0.99

2.65 ± 0.95

2.99 ± 0.50

3.06 ± 0.60

0.521

 PFR/EDV

4.46 ± 1.41

3.68 ± 1.41

3.54 ± 1.27

3.96 ± 0.80

3.97 ± 1.06

0.348

 DVR80%

0.67 ± 0.15

0.71 ± 0.08

0.78 ± 0.08*

0.78 ± 0.07*

0.77 ± 0.06*

0.017

Strain

      

 GRPS (%)

20.55 ± 4.39

24.68 ± 11.61

27.48 ± 13.42

26.40 ± 8.55

19.45 ± 10.17&

0.239

 GCPS (%)

− 16.14 ± 2.27

− 15.62 ± 3.73

− 18.67 ± 6.89

− 18.14 ± 4.37

− 15.56 ± 6.33

0.407

 GLPS (%)

− 10.21 ± 3.15

− 9.74 ± 2.78

− 9.38 ± 3.71

− 8.71 ± 2.68

− 6.59 ± 2.90*#

0.084

 GPSSR-R

1.56 ± 0.33

1.63 ± 0.53

1.79 ± 0.89

1.81 ± 0.68

1.54 ± 0.18

0.491

 GPSSR-C

− 1.03 ± 0.19

− 0.94 ± 0.14

− 1.10 ± 0.25

− 1.09 ± 0.41

− 1.04 ± 0.08

0.587

 GPSSR-L

− 0.88 ± 0.34

− 0.81 ± 0.19

− 0.71 ± 0.18

− 0.81 ± 0.30

− 0.71 ± 0.20

0.326

 GPDSR-R

− 2.14 ± 0.60

− 1.97 ± 0.48

− 2.97 ± 1.24

− 2.74 ± 1.38

− 1.69 ± 0.61&

0.021

 GPDSR-C

1.63 ± 0.32

1.55 ± 0.24

1.81 ± 0.94

1.66 ± 0.54

1.42 ± 0.41

0.601

 GPDSR-L

1.09 ± 0.46

0.96 ± 0.35

0.87 ± 0.44

0.81 ± 0.32

0.59 ± 0.25*

0.082

  1. C circumferential, EDD end-diastolic diameter, EDV end-diastolic volume, ESD end-systolic diameter, EF ejection fraction, ESV end-systolic volume, GPS global peak strain, GPDSR global peak diastolic strain rate, GPSSR global peak systolic strain rate, L longitudinal, LV left ventricular, LVRI left ventricular remodelling index, PER peak ejection rate, PFR peak filling rate, R radial; SV stroke volume
  2. * P < 0.05 versus before modelling; #P < 0.05 versus 2 months after modelling. &P < 0.05 versus 6 months after modelling
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Cardiovascular Diabetology

ISSN: 1475-2840