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Table 1 Characteristics of female and male patients with a dual diagnosis of type 2 diabetes and cardiovascular disease 2012–2018

From: Gender disparities in time-to-initiation of cardioprotective glucose-lowering drugs in patients with type 2 diabetes and cardiovascular disease: a Danish nationwide cohort study

 

All

(n = 70.538)

Female

(n = 27.133)

Male

(n = 43.405)

Missing values

Age in years (mean, SD)

69.9 (11.9)

72.1 (12.3)

68.6 (11.3)

0.0

Diabetes duration in years (mean, SD)

3.7 (5.8)

4.1 (6.1)

3.5 (5.6)

0.0

Education level (n, %)

   

3.7a

 0–10 years

26,358 (38.8)

12,556 (48.5)

13,802 (32.8)

 

 10–15 years

33,775 (49.7)

11,048 (42.6)

22,727 (54.1)

 

 > 15 years

7795 (11.5)

2305 (8.9)

5490 (13.1)

 

HbA1c mmol/mol (mean, SD)

55 (16)

54 (15)

56 (16)

22.4a

LDL mol/l (mean, SD)

2.3 (1.0)

2.4 (1.1)

2.3 (1.0)

33.1a

Estimated GFR ml-min per 1.73m2 (mean, SD)

69 (22)

67 (22)

71 (21)

61.0a

Use of cardioprotective glucose-lowering drug prior to or initiated at index date (n, %)

3256 (4.6)

1184 (4.4)

2072 (4.8)

0.0

Use of SGLT2 inhibitor prior to or initiated at index date (n, %)

1005 (1.4)

329 (1.2)

676 (1.6)

0.0

Use of GLP1 analogue prior to or initiated at index date (n, %)

2565 (3.6)

956 (3.5)

1609 (3.7)

0.0

Lipid-lowering drug (n, %)

45,427 (64.4)

16,719 (61.6)

28,708 (66.1)

0.0

Antihypertensive drug (n, %)

60,376 (85.6)

23,636 (87.1)

36,740 (84.6)

0.0

Antiplatelet or anticoagulant drug (n, %)

45,923 (65.1)

16,932 (62.4)

28,991 (66.8)

0.0

Latest diagnosis at index date (n, %)

   

0.0

 CVD

32,178 (45.6)

13,147 (48.5)

19,031 (43.8)

 

 CVD and T2D

579 (0.8)

176 (0.6)

403 (0.9)

 

 T2D

37,781 (53.6)

13,810 (50.9)

23,971 (55.2)

 

CVD type (n, %)

   

0.0

 Ischemic heart disease

34,443 (48.8)

12,081 (44.5)

22,362 (51.5)

 

 Heart failure

10,982 (15.6)

4494 (16.6)

6488 (14.9)

 

 Peripheral arterial disease

8583 (12.2)

3410 (12.6)

5173 (11.9)

 

 Cerebrovascular disease

16,530 (23.4)

7148 (26.3)

9382 (21.6)

 
  1. SGLT2 Sodium-Glucose Transport Protein 2; GLP1 Glucagon-Like Peptide 1; DPP4 Dipeptidyl Peptidase-4; HbA1c Hemoglobin A1c (International Federation of Clinical Chemistry; National Glycohemoglobin Standardization); LDL low-density lipoprotein cholesterol; GFR glomerular filtration rate
  2. aThere were missing values in education level and the biochemical variables i.e. HbA1c, LDL, and eGFR. We imputed 10 datasets for these variables