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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Effects of single and multiple sessions of lower body diastole-synchronized compressions using a pulsating pneumatic suit on endothelium function and metabolic parameters in patients with type 2 diabetes: two controlled cross-over studies

Fig. 1

Study design and measures for both Study 1 and 2. A: Study 1 with 16 patients taking a single 20 min DSCD/control session. ACh; acetylcholine, control; simulated session (diastole synchronized compression/decompression session at 5 mmHg), CBF; cutaneous blood flow, DSCD; diastole synchronized compression/decompression session at 65 mmHg, RHI; reactive hyperaemia index. Arm-1: one DSCD visit followed by one control visit. Arm-2: one control visit followed by one DSCD visit. RHI was measured with Endo-PAT®, CBF was measured with Laser Doppler flowmetry (LDF), blood pressure was measured with SphygmoCor®. Blood samples were taken at fasting and again after the end of the DSCD/control session. Breakfast was eaten 50 min prior to starting CGMS stabilized recording (T0) (indicated in dark pink). Light pink corresponds to the 45 min needed to achieve CGMS stabilization. DSCD/control sessions started one hour (T60) after the start of CGMS recording and lasted for 20 min. Vascular assessment was performed twice: before and after DSCD/Control session. B: Study 2 with 38 patients taking three 60 min DSCD sessions in a week for three months. CBF; cutaneous blood flow, control; no session was performed, DSCD; diastole synchronized compression/decompression session at 65 mmHg, FMD; flow-mediated dilation, SF-36; 36-Item Short Form Survey (a self-questionnaire to measure health status), VTI; speed of hyperaemia response. Arm-1: three 60 min DSCD sessions a week within three months followed by a 3-month control period (reverse for Arm-2). Blood pressure was measured with SphygmoCor®. CBF was measured with Laser Doppler flowmetry (LDF)

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Cardiovascular Diabetology

ISSN: 1475-2840