Fig. 1

Position of apoC1 gen on chromosome 19 within a cluster encompassing the apoE, apoC1’, apoC2 and apoC4 genes. Genes are shown in green boxes, with their respective length indicated below. Black arrows indicate gene orientation. The length of noncoding regions between genes are indicated in italic. ApoC1’ pseudogene is hatched in grey. Regulatory regions are shown in brown (ME 1 and ME2) and yellow boxes (HCR1 and HCR2). ME and HCR regions promote gene expression in macrophages and hepatocyte, respectively. Transcription factors involved in the regulation of APOC1 gene are shown in ovals, with activators in green and repressors in red. Kb kilobase, ME multienhancer, HCR hepatic control region, LXR liver X receptor, PPAR peroxisome proliferator-activated receptor, Znf, Zfp zinc finger protein