Table 1 Baseline characteristics of included studies in patients with T2DM and CKD

Finerenone vs placebo

FIDELIO-DKD

25 to < 75

6674

2833

3841

65.4 ± 8.9

65.7 ± 9.2

1953

2030

N/A

7.7 ± 1.3

7.7 ± 1.4

44.4 ± 12.5

44.3 ± 12.6

16.6 ± 8.8

16.6 ± 8.8

FIGARO-DKD

25 to 90

7352

3686

3666

64.1 ± 9.8

5107

31.4 ± 6.0

7.7 ± 1.4

67.8 ± 21.7

14.5 ± 8.5

ARTS-DN

 ≥ 30

821

727

94

64.33 ± 9.20

63.26 ± 8.68

570

69

31.75 ± 5.57

32.49 ± 5.27

7.6 ± 1.3

7.6 ± 1.3

66.9 ± 21.9

72.2 ± 20.4

N/A

SGLT2i vs placebo

EMPA-REG

30 to 59

1819

1212

607

67.1 ± 7.6

67.1 ± 8.2

816

418

31.0 ± 5.5

30.9 ± 5.4

8.07 ± 0.86

8.03 ± 0.85

48.4 ± 8.2

48.6 ± 7.8

N/A

CANVAS

30 to < 60

2039

1110

929

67.6 ± 7.8

67.6 ± 7.6

659

527

32.1 ± 5.9

32.5 ± 6.2

8.3 ± 1.0

8.3 ± 0.9

49.2 ± 7.8

49.0 ± 8.3

16.1 ± 8.4

15.7 ± 8.2

DECLARE-TIMI 58

 < 60

1265

606

659

67.3 ± 6.6

814

34.5 ± 6.0

8.2 ± 1.2

51.4 ± 7.2

14.5 ± 8.9

CREDENCE

30 to < 90

4401

2202

2199

62.9 ± 9.2

63.2 ± 9.2

1440

1467

31.4 ± 6.2

31.3 ± 6.2

8.3 ± 1.3

8.3 ± 1.3

56.3 ± 18.2

56.0 ± 18.3

15.5 ± 8.7

16.0 ± 8.6

VERTIS CV

30 to < 60

1807

1199

608

N/A

N/A

N/A

N/A

N/A

N/A

DAPA-CKD

25 to 75

2906

1455

1451

64.1 ± 9.8

64.7 ± 9.5

961

980

30.2 ± 6.2

30.4 ± 6.3

7.8 ± 1.7

7.8 ± 1.6

44.0 ± 12.6

43.6 ± 12.6

13.7

13.8

SCORED

25 to 60

10,584

5292

5292

69

69

2945

2885

31.9

31.7

8.3

8.3

44.4

44.7

N/A

Cherney 2021

15 to < 30

277

184

93

67.1 ± 9.8

68.0 ± 8.3

93

42

31.5 ± 5.8

31.7 ± 5.7

8.3 ± 0.9

8.4 ± 1.1

23.9 ± 4.6

24.1 ± 4.4

19.1 ± 9.2

20.7 ± 8.9

GLP-1 RA vs placebo

LEADER

 < 60

2158

1116

1042

67.3 ± 7.5

67.3 ± 7.5

691

631

32.6 ± 6.4

32.7 ± 6.6

8.7 ± 1.6

8.6 ± 1.5

45.5 ± 10.9

45.8 ± 10.8

15.4 ± 8.7

14.9 ± 8.5

REWIND

15 to < 60

2199

1081

1118

N/A

N/A

N/A

N/A

N/A

N/A

HARMONY

30 to < 60

2222

1098

1124

N/A

N/A

N/A

N/A

N/A

N/A

EXSCEL

30 to < 60

3177

1157

1620

66.5

1815

32.8

8.1

49.2

N/A

PIONEER-6

30 to < 60

856

434

422

N/A

N/A

N/A

N/A

N/A

N/A

SUSTAIN-6

 < 60

939

469

470

N/A

N/A

N/A

N/A

N/A

N/A

AMPLITUDE-O

 < 71.5 mg/ml/1.73 m²

2218

1037

666

N/A

N/A

N/A

N/A

N/A

N/A