Table 1 Baseline demographic and disease characteristics among patients with samples available at baseline
Characteristic | CANA (n = 2353) | PBO (n = 1178) | Total (N = 3531) |
|---|---|---|---|
Age, year | 62.9 ± 7.9 | 62.6 ± 7.8 | 62.8 ± 7.9 |
Female sex, n (%) | 779 (33.1) | 392 (33.3) | 1171 (33.2) |
Current smoker, n (%) | 410 (17.4) | 242 (20.5) | 652 (18.5) |
History of hypertension, n (%) | 2067 (87.8) | 1041 (88.4) | 3108 (88.0) |
History of HF, n (%) | 296 (12.6) | 171 (14.5) | 467 (13.2) |
Duration of diabetes, year | 13.6 ± 7.5 | 13.3 ± 7.6 | 13.5 ± 7.5 |
Prior history of CV disease, n (%) | 1410 (59.9) | 695 (59.0) | 2105 (59.6) |
Prior history of HF, n (%) | 171 (14.5) | 296 (12.6) | 467 (13.2) |
BMI, kg/m2 | 32.7 ± 6.1 | 32.6 ± 6.2 | 32.7 ± 6.1 |
Systolic BP, mmHg | 136.3 ± 15.9 | 137.1 ± 15.7 | 136.6 ± 15.8 |
Diastolic BP, mmHg | 77.4 ± 9.8 | 78.1 ± 9.8 | 77.6 ± 9.8 |
HbA1c, % | 8.2 ± 0.9 | 8.1 ± 0.9 | 8.2 ± 0.9 |
HDL, mg/dL (Median [IQR]) | 44 [38–52] | 44 [38–53] | 44 [38–52] |
LDL, mg/dL (Median [IQR]) | 88 [63–108] | 82 [63–107] | 82 [63–108] |
AST, U/L | 23.4 (9.8) | 23.7 (12.2) | 23.5 (10.6) |
ALT, U/L | 27.0 (14.8) | 27.3 (13.9) | 27.1 (14.5) |
NTproBNP, ng/mL (Median [IQR]) | 90 [42–205] | 96 [42–196] | 92 [42–204] |
eGFR, mL/min/1.73 m2 | 77.1 ± 18.8 | 76.7 ± 19.0 | 77.0 ± 18.8 |
ACR, mg/g (Median [IQR]) | 11.6 (6.5–34.4) | 11.5 (6.2–36.0) | 11.5 (6.4–34.7) |
Normal/mildly increased, n/total (%) | 1704/2341 (72.8) | 844/1173 (72.0) | 2548/3514 (72.5) |
Moderately increased, n/total (%) | 519/2341 (22.2) | 252/1173 (21.5) | 771/3514 (21.9) |
Severely increased, n/total (%) | 118/2341 (5.0) | 77/1173 (6.6) | 195/3514 (5.5) |