Polygenic scores for low lung function and the future risk of adverse health outcomes

Table 2 Univariate regression for mean systolic blood pressure by quartiles of PGS (n = 27,438)

FEV₁ score	Q1 (highest) (n = 6859)	Q2 (n = 6860)	Q3 (n = 6860)	Q4 (lowest) (n = 6859)	p-value §	Per 1 SD increase (mmHg)
Model 1	140.5 (140.0–141.0)	141.5 (141.0–142.0)	141.2 (140.8–141.7)	141.4 (141.0–141.9)	0.005	−0.389**
Model 2	140.7 (140.3–141.1)	141.4 (141.0–141.8)	141.2 (140.8–141.6)	141.5 (141.1–141.9)	0.008	−0.332**
FVC score	Q1 (highest) (n = 6859)	Q2 (n = 6860)	Q3 (n = 6860)	Q4 (n = 6859)	p-value	Per 1 SD increase
Model 1	140.5 (140.0–141.0)	141.4 (140.9–141.9)	141.1 (140.6–141.5)	141.8 (141.3–142.2)	< 0.001	−0.455***
Model 2	140.7 (140.3–141.1)	141.3 (140.9–141.7)	141.0 (140.6–141.4)	141.7 (141.3–142.1)	0.001	−0.352**

Model 1 unadjusted, Model 2 controlling for age, sex, height, weight, smoking, prevalent diabetes, inhaled corticosteroid use and principal components 1–5 of population structures. § p-value Q1 vs. Q4. P < 0.05 * P < 0.01 ** P < 0.001*** Quartile cut off points for FEV1 score: Q1=−0.32 to 0.61, Q2=−0.49 to −0.32, Q3=−0.65 to −0.49, Q4=−2.52 to −0.65. Quartile cut off point for FVC score: Q1=−0.27 to 0.53, Q2=−0.42 to −0.27, Q3=−0.57 to −0.42, Q4=−1.36 to −0.57

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