Table 1 Baseline association between risk factors and FVC-PGS (n = 27 438)
From: Polygenic scores for low lung function and the future risk of adverse health outcomes
|  | Q1 (highest) − 0.27 to 0.53 (n = 6859) | Q2 − 0.42 to − 0.27 (n = 6860) | Q3 − 0.57 to − 0.42 (n = 6860) | Q4 (lowest) − 1.36 to − 0.57 (n = 6859) | p-value |
|---|---|---|---|---|---|
Age (years) | 58.0 (± 7.6) | 58.2 (± 7.6) | 58.1 (± 7.7) | 58.1 (± 7.7) | 0.550 |
Height (cm) | 168.4 (± 8.9) | 168.6 (± 8.8) | 168.7 (± 8.8) | 168.8 (± 8.9) | 0.020 |
BMI (kg/m2) | 25.6 (± 3.9) | 25.8 (± 4.0) | 25.8 (± 4.0) | 25.9 (± 4.0) | < 0.001 |
Systolic BP (mmHg) | 140.5 (± 20.0) | 141.4 (± 20.0) | 141.1 (± 19.9) | 141.8 (± 20.1) | 0.001 |
Current smokers (%) | 27.8 | 28.1 | 28.6 | 28.1 | 0.149 |
ApoA1* | 156.9 (± 27.5) | 157.0 (± 28.2) | 156.6 (± 28.5) | 156.6 (± 28.6) | 0.421 |
ApoB* | 106.9 (± 26.0) | 106.5 (± 26.5) | 107.2 (± 26.2) | 107.6 (± 25.5) | 0.050 |
Prevalent CE (%) | 1.8 | 1.9 | 1.9 | 2.1 | 0.278 |
Prevalent DM (%) | 3.7 | 4.3 | 4.3 | 5.6 | < 0.001 |
Inhaled corticosteroid use (%) | 1.9 | 2.1 | 2.1 | 2.2 | 0.251 |
Higher education (%) | 15.2 | 14.4 | 14.1 | 13.2 | 0.001 |
Low physical activity (%)** | 19.7 | 19.9 | 20.8 | 20.3 | 0.241 |