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Table 4 Univariate analysis for clinical outcome

From: Prognostic value of coronary microvascular dysfunction assessed by coronary angiography-derived index of microcirculatory resistance in diabetic patients with chronic coronary syndrome

 

All

DM

Non-DM

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

caIMR ≥ 25

2.857 (1.472–5.542)

0.002

2.731 (1.095–6.814)

0.031

1.786 (0.626–5.099)

0.278

Male

1.955 (0.901–4.245)

0.090

2.469 (0.929–6.563)

0.070

1.605 (0.448–5.755)

0.468

BMI

1.045 (0.949–1.150)

0.375

0.961 (0.853–1.083)

0.514

1.101 (0.925–1.310)

0.279

Hyperlipidemia

0.594 (0.232–1.520)

0.277

0.387 (0.091–1.641)

0.198

1.067 (0.295–3.856)

0.922

Hypertension

0.734 (0.387–1.392)

0.343

0.473 (0.217–1.032)

0.060

1.245 (0.390–3.971)

0.711

LVEF

0.907 (0.878–0.937)

< 0.001

0.929 (0.895–0.965)

< 0.001

0.888 (0.830 − 0.951)

0.001

Age

1.012 (0.979–1.046)

0.488

0.995 (0.951–1.041)

0.820

1.022 (0.967–1.080)

0.448

Smoking history

0.785 (0.362–1.704)

0.540

1.379 (0.576–3.303)

0.471

0.218 (0.029–1.673)

0.143

Atrial fibrillation

1.462 (0.450–4.744)

0.527

1.205 (0.284–5.117)

0.800

1.589 (0.208–12.155)

0.656

CAD

1.050 (0.253–4.356)

0.947

0.936 (0.126–6.942)

0.949

0.811 (0.106–6.204)

0.840

CKD

2.210 (0.928–5.264)

0.073

1.499 (0.565–3.975)

0.416

1.761 (0.230–13.471)

0.586

PCI performed

1.781 (0.746–4.250)

0.194

1.031 (0.386–2.754)

0.951

4.447 (0.581–34.035)

0.151

FBG

1.090 (0.962–1.235)

0.176

0.935 (0.790–1.107)

0.434

1.247 (0.745–2.088)

0.400

HbA1c

1.238 (1.041–1.472)

0.016

1.000 (0.763–1.311)

0.999

1.109 (0.597–2.060)

0.744

TC

0.800 (0.553–1.157)

0.236

0.772 (0.489–1.219)

0.267

0.821 (0.449–1.504)

0.524

LDL-C

0.739 (0.482–1.133)

0.166

0.711 (0.411–1.230)

0.223

0.764 (0.385–1.515)

0.440

Cr

1.008 (0.995–1.022)

0.219

1.011 (0.997–1.026)

0.132

0.994 (0.964–1.025)

0.694

eGFR

0.996 (0.982–1.011)

0.619

0.991 (0.975–1.007)

0.264

1.012 (0.986–1.039)

0.360

caIMR

1.027 (1.003–1.051)

0.028

1.015 (0.986–1.044)

0.310

1.023 (0.976–1.073)

0.334

Aspirin

0.463 (0.205–1.048)

0.065

0.606 (0.182–2.024)

0.416

0.272 (0.085–0.868)

0.028

P2Y12 receptor antagonist

0.874 (0.416–1.836)

0.722

0.371(0.156–0.883)

0.025

1.925 (0.431–8.609)

0.391

Statin

0.313 (0.123 − 0.800)

0.015

0.654 (0.196–2.181)

0.490

0.161 (0.036–0.722)

0.017

ACEI/ARB

1.280 (0.680 − 2.410)

0.445

1.058 (0.480–2.332)

0.889

1.300 (0.451–3.747)

0.627

Beta blocker

1.111 (0.590 − 2.093)

0.744

1.474 (0.655–3.317)

0.348

0.729 (0.254–2.088)

0.556

CCB

1.258 (0.674 − 2.347)

0.470

1.418 (0.655–3.072)

0.375

1.585 (0.531–4.734)

0.409

  1. DM diabetes mellitus, caIMR coronary angiography-derived index of microcirculatory resistance, BMI body mass index, PCI percutaneous coronary intervention, CKD chronic kidney disease, LVEF left ventricular ejection fraction, FBG fasting blood glucose, HbA1c hemoglobin A1c, TC total cholesterol, LDL-C low-density lipoprotein-cholesterol, Cr creatinine, eGFR estimate glomerular filtration rate, ACEI/ARB angiotensin-converting-enzyme inhibitors/angiotensin receptor blockers, CCB calcium channel blocker, CI confidence interval, HR hazard ratio
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Cardiovascular Diabetology

ISSN: 1475-2840