Table 3 Association of Δmetabolites with mortality
Metabolite | Δ metabolites | Fasting metabolites | ||||||
|---|---|---|---|---|---|---|---|---|
Model 1 | Model 2 | Model 1 | Model 2 | |||||
HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
Hydroxyphenylacetate | 1.29 (1.07–1.56) | 0.007 | 1.29 (1.06–1.57) | 0.010 | 0.98 (0.82–1.17) | 0.82 | 0.96 (0.80–1.15) | 0.64 |
PC 32:0 | 0.86 (0.73–1.00) | 0.053 | 0.81 (0.69–0.95) | 0.011 | 1.10 (0.91–1.32) | 0.31 | 1.05 (0.87–1.27) | 0.59 |
TAG 56:5 | 1.26 (1.04–1.53) | 0.02 | 1.27 (1.03–1.55) | 0.023 | 1.03 (0.86–1.23) | 0.73 | 0.95 (0.79–1.14) | 0.56 |
Glucuronate | 0.85 (0.74–0.99) | 0.033 | 0.84 (0.72–0.98) | 0.028 | 0.99 (0.83–1.18) | 0.87 | 0.95 (0.78–1.14) | 0.56 |
⍺-ketoglutarate | 1.21 (1.00–1.46) | 0.052 | 1.22 (1.01–1.46) | 0.037 | 1.12 (0.92–1.37) | 0.24 | 1.06 (0.86–1.30) | 0.61 |
NMMA | 0.86 (0.72–1.02) | 0.09 | 0.83 (0.69–1.00) | 0.045 | 1.11 (0.93–1.33) | 0.26 | 1.10 (0.91–1.32) | 0.33 |
Sucrose | 1.22 (1.01–1.46) | 0.037 | 1.21 (0.99–1.47) | 0.058 | 0.95 (0.76–1.19) | 0.67 | 0.88 (0.70–1.11) | 0.27 |
Propionate | 1.27 (1.02–1.59) | 0.032 | 1.25 (0.99–1.59) | 0.06 | 0.97 (0.76–1.24) | 0.80 | 0.99 (0.77–1.27) | 0.92 |