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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathway

Fig. 2

Nrg4 alleviates cardiac fibrosis and cardiomyocyte apoptosis. a Left ventricle stained with HE (original magnification ✕ 200). b Interstitial fibrosis of the left ventricles by Masson staining. The collagen fibres are stained blue (with arrows, original magnification ✕ 200). c Comparison of the collagen volume fraction (CVF) in each group. d–g Western blot and quantitative analysis of apoptosis-related proteins (Bax, Caspase-3 and Bcl-2). h Representative immunofluorescent images with TUNEL (green) and DAPI (blue) staining (original magnification ✕ 200). i Comparison of the apoptosis index in each group. Data are presented as the mean ± SD (n = 6 per group). Significant differences are depicted with *P < 0.05

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Cardiovascular Diabetology

ISSN: 1475-2840