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Table 3 Risk of CHD during follow-up in GENEDIAB and GENESIS cohorts by allelic variations in LTL-related genes

From: Leukocyte telomere length, allelic variations in related genes and risk of coronary heart disease in people with long-standing type 1 diabetes

Gene

SNP

Genetic model

and risk allele

Hazard ratio

(95% CI)

p

TERC

rs12696304

Recessive G

2.37 (1.34–5.01)

0.007

TERC

rs2293607

Recessive C

2.98 (1.30–5.88)

0.01

TERC

rs1317082

Recessive G

2.76 (1.21–5.49)

0.02

TERC

rs10936601

Recessive T

2.77 (1.32–5.23)

0.009

TERC

rs16847897

Dominant G

1.16 (0.52–3.31)

0.77

NAF1

rs7675998

Dominant T

1.57 (1.04–2.39)

0.03

NAF1

rs6823843

Recessive T

2.05 (1.30–3.33)

0.002

TERT

rs7726159

Codominant C

1.39 (1.03–1.90)

0.03

TERT

rs2736098

Codominant A

1.07 (0.74–1.52)

0.72

TERT

rs401681

Dominant T

1.32 (0.84–2.19)

0.24

TNKS

rs11991621

Dominant C

1.73 (0.63–7.13)

0.32

TNKS

rs12549064

Recessive A

1.24 (0.79–1.99)

0.35

TNKS

rs10903314

Dominant C

3.60 (1.32–14.83)

0.009

TNKS

rs6990300

Dominant G

1.23 (0.82–1.85)

0.32

TNKS

rs11249943

Codominant A

1.21 (0.84–1.78)

0.31

TNKS

rs17150478

Codominant A

1.04 (0.72–1.53)

0.85

TERF1

rs2981084

Dominant A

1.24 (0.67–2.57)

0.52

STN1

rs10786775

Dominant G

1.15 (0.70– 1.83)

0.56

STN1

rs2487999

Dominant T

1.30 (0.80–2.05

0.28

STN1

rs9420907

Dominant C

1.04 (0.67–1.57)

0.87

STN1

rs11591710

Codominant C

1.01 (0.43–2.23)

0.99

MEN1

rs669976

Codominant T

1.91 (1.11–13.53)

0.02

MEN1

rs524386

Codominant T

1.68 (0.93–3.40)

0.09

MEN1

rs2957154

Codominant C

1.66 (1.09–2.54)

0.02

MRE11

rs12270338

Codominant C

1.12 (0.80–1.60)

0.51

MRE11

rs13447720

Recessive C

1.34 (0.55–2.78)

0.49

BICD1

rs2630578

Codominant C

1.55 (1.04–2.27)

0.03

BICD1

rs2125173

Dominant G

1.81 (1.09–2.92)

0.02

BICD1

rs10506083

Dominant A

1.24 (0.72–2.32)

0.45

BICD1

rs10844149

Dominant A

1.39 (0.94–2.08)

0.10

BICD1

rs1151026

Recessive G

1.94 (0.58–4.76)

0.25

MPHOSPH06

rs2967374

Codominant A

1.02 (0.71–1.45)

0.89

ZNF208

rs8105767

Dominant G

1.52 (0.93–2.39)

0.09

  1. Hazard Ratio computed by Cox proportional hazards survival regression analysis for the risk allele of SNPs in pooled GENEDIAD/GENESIS cohorts. Adjusted for cohort membership, sex, age, BMI, duration of diabetes, HbA1c, eGFR, UAC, tobacco smoking, and use of ACE-Inhibitors, antihypertensive and lipid lowering drugs at baseline
  2. BICD1 Bicaudal D homolog 1 MEN1 Multiple Endocrine Neoplasia type 1 MPHOSPH6 M-phase Phosphoprotein 6 MRE11A Meiotic Recombination 11 homolog A NAF1 Nuclear Assembly Factor 1 STN1 STN1 Subunit of CST Complex TERC Telomerase RNA Component TERF1 Telomeric repeat-binding factor 1 TERT Telomerase Reverse Transcriptase TNKS Tankyrase ZNF208: Zinc Finger Protein 208
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Cardiovascular Diabetology

ISSN: 1475-2840