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Table 2 Myocardial infarction at baseline and CHD risk during follow-up by baseline LTL in the GENEDIAB cohort

From: Leukocyte telomere length, allelic variations in related genes and risk of coronary heart disease in people with long-standing type 1 diabetes

 

Crude

Adjusted Model 1

Adjusted Model 2

OR or HR

(95% CI)

p

OR or HR

(95% CI)

p

HR

(95% CI)

p

Previous MI at baseline*

      

 T1 vs T3

3.76 (1.12–17.08)

0.03

7.84 (1.65–54.57)

0.008

  

 T1 vs T2

2.85 (0.93–10.64)

0.07

4.56 (1.15–22.61)

0.03

  

 T2 vs T3

1.32 (0.28–6.86)

0.72

1.72 (0.28–12.36)

0.55

  

 Z-score log[LTL]

0.60 (0.36–0.99)

0.05

0.31 (0.14–0.62)

0.0007

  

CHD at follow-up

      

 T1 vs T3

2.55 (1.26–5.57)

0.009

3.06 (1.37–7.43)

0.006

3.14 (1.39–7.70)

0.005

 T1 vs T2

1.56 (0.87–2.85)

0.14

1.84 (0.91–3.84)

0.09

1.63 (0.80–3.39)

0.18

 T2 vs T3

1.63 (0.78–3.63)

0.20

1.66 (0.72–4.08)

0.24

1.92 (0.81–4.91)

0.14

 Z-score log[LTL]

0.76 (0.58– 1.01)

0.06

0.71 (0.52–0.96)

0.03

0.73 (0.54–0.98)

0.03

  1. *Odds ratio (OR) computed by logistic regression analyses and Hazard Ratio (HR) computed by Cox proportional hazards survival regression analysis for 1 SD of log[LTL] and for tertiles (T) of LTL distribution. T1 (short LTL), T2 (intermediate LTL), T3 (long LTL). Model 1: adjusted for sex, age, BMI, duration of diabetes, HbA1c, eGFR, UAC, tobacco smoking and use of ACE-Inhibitors, antihypertensive and lipid lowering drugs at baseline. Model 2: Model 1 plus adjustment for previous history of myocardial infarction at baseline. Number of participants with/without a previous myocardial infarction (MI) at baseline by LTL tertiles: 11/79 (T1), 4/82 (T2) and 3/81 (T3). Number of participants with/without incident CHD during follow-up by LTL tertiles: 25/65 (T1), 20/72 (T2) and 10/68 (T3)