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Table 1 Comparisons in baseline data between the MET group and the MET-DUL group [(\(\overline{x}\) ± s), n (%)]

From: Effects of dulaglutide on endothelial progenitor cells and arterial elasticity in patients with type 2 diabetes mellitus

Variables

MET

MET-DUL

P value

Number

30

30

–

Gender male (%)

17 (56.7%)

18 (60.0%)

0.76

Age (year)

43.5 ± 4.4

42.9 ± 5.3

0.68

Diabetes duration (month)

9.3 ± 1.4

8.8 ± 1.3

0.48

BMI (kg/m2)

26.8 ± 2.7

27.1 ± 2.5

0.21

SBP (mmHg)

141.3 ± 14.2

139.4 ± 12.3

0.57

DBP (mmHg)

94.1 ± 11.4

93.6 ± 12.2

0.77

FPG (mmol/l)

7.4 ± 1.1

7.5 ± 0.9

0.78

FCP (ng/ml)

1.2 ± 0.3

1.1 ± 0.2

0.80

HbA1c (%; mmol/mol)

7.2 ± 0.2; 55.2 ± 1.6

7.1 ± 0.3; 54.1 ± 1.8

0.78

TG (mmol/l)

2.2 ± 0.8

2.3 ± 0.9

0.78

TCH (mmol/l)

5.7 ± 1.3

5.6 ± 1.2

0.77

HDL-C (mmol/l)

1.4 ± 0.3

1.3 ± 0.2

0.70

LDL-C (mmol/l)

3.5 ± 0.5

3.4 ± 0.3

0.76

NO (μmol/l)

68.9 ± 14.7

71.6 ± 13.9

0.31

VEGF (pmol/ml)

211.7 ± 25.8

208.3 ± 26.7

0.42

SDF-1α (pmol/ml)

2056.1 ± 512.3

1989.6 ± 531.7

0.31

CRP (mg/dl)

5.8 ± 1.1

5.7 ± 1.3

0.72

TNF-α (pg/ml)

17.9 ± 7.8

16.4 ± 7.1

0.59

IL-6 (ng/l)

126.1 ± 32.3

135.6 ± 30.8

0.29

AGEs (ng/ml)

918.9 ± 104.5

922.4 ± 106.8

0.53

EPCs (/106 cell)

27.2 ± 12.3

26.1 ± 13.4

0.69

baPWV (cm/s)

1587.4 ± 103.5

1576.7 ± 111.6

0.80

EPA (OD value)

0.53 ± 0.06

0.53 ± 0.08

0.90

EAA (cell numbers)

35.95 ± 9.73

36.82 ± 10.75

0.74

EMA (cell numbers)

18.67 ± 8.32

18.89 ± 8.81

0.89

ETF (μm)

3284.21 ± 245.46

3293.78 ± 248.73

0.80

  1. Data are presented mean ± standard deviations or numbers (%)
  2. MET metformin monotherapy group, MET-DUL metformin combined with dulaglutide treatment group, BMI body mass index, SBP systolic pressure, DBP diastolic pressure, FPG fasting plasma glucose, FCP fasting C peptide, HbA1c glycated hemoglobin A1c, TG triglyceride, TCH total cholesterol, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, NO nitric oxide, VEGF vascular endothelial growth factor, SDF-1α stromal cell derived factor-1α, CRP C-reactive protein, TNF-α tumour necrosis factor-α, IL-6 interleukin-6, AGEs advanced glycation end products, EPCs endothelial progenitor cells, baPWV brachial–ankle pulse wave velocity, EPA endothelial progenitor cells proliferative ability, EAA endothelial progenitor cells adhesion ability, EMA endothelial progenitor cells migration ability, ETF endothelial progenitor cells tubule forming ability