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Table 2 Distribution of study covariates and hospital outcomes of WOMEN with and without T2DM with infective endocarditis in Spain (2016–2020), before and after propensity score matching (PSM)

From: Sex-related disparities in the incidence and outcomes of infective endocarditis according to type 2 diabetes mellitus status in Spain, 2016–2020

 

Before PSM

After PSM

T2DM

No T2DM

p-value

T2DM

No T2DM

p-value

N, (incidence per 100,000 women per year)

839 (11.91)

2469 (4.01)

 < 0.001

839

839

NA

Age, mean (SD)

75.58 (9)

73.13 (12.57)

 < 0.001

75.58 (9)

76.81 (10.12)

0.008

40–66 years old, n (%)

122 (14.54)

678 (27.46)

 < 0.001

122 (14.54)

122 (14.54)

0.008

67–75 years old, n (%)

264 (31.47)

568 (23.01)

264 (31.47)

209 (24.91)

 ≥ 76 years old, n (%)

453 (53.99)

1223 (49.53)

453 (53.99)

508 (60.55)

Acute renal disease, n (%)

205 (24.43)

489 (19.81)

0.004

205 (24.43)

200 (23.84)

0.775

Chronic renal disease, n (%)

257 (30.63)

394 (15.96)

 < 0.001

257 (30.63)

244 (29.08)

0.488

Congestive heart failure, n (%)

146 (17.4)

254 (10.29)

 < 0.001

146 (17.4)

129 (15.38)

0.262

COPD, n (%)

35 (4.17)

74 (3)

0.100

35 (4.17)

37 (4.41)

0.810

Dementia, n (%)

34 (4.05)

60 (2.43)

0.015

34 (4.05)

31 (3.69)

0.704

Atrial fibrillation, n (%)

319 (38.02)

872 (35.32)

0.159

319 (38.02)

308 (36.71)

0.579

COVID-19, n (%)

6 (0.72)

13 (0.53)

0.532

6 (0.72)

6 (0.72)

0.999

Ischemic heart disease, n (%)

114 (13.59)

229 (9.28)

 < 0.001

114 (13.59)

110 (13.11)

0.774

Previous aortic valve disease, n (%)

206 (24.55)

633 (25.64)

0.533

206 (24.55)

196 (23.36)

0.567

Previous mitral valve disease, n (%)

268 (31.94)

788 (31.92)

0.988

268 (31.94)

263 (31.35)

0.793

Previous pulmonic valve disease, n (%)

2 (0.24)

6 (0.24)

0.981

2 (0.24)

1 (0.12)

0.563

Previous tricuspid valve disease, n (%)

94 (11.2)

233 (9.44)

0.139

94 (11.2)

97 (11.56)

0.818

Prosthetic valve carriers, n (%)

83 (9.89)

241 (9.76)

0.912

83 (9.89)

87 (10.37)

0.746

CCI index, mean (SD)

1.41 (0.99)

1.13 (1)

 < 0.001

1.41 (0.99)

1.32 (1.07)

0.097

Periannular complications / atrioventricular block, n (%)

45 (5.36)

93 (3.77)

0.046

45 (5.36)

32 (3.81)

0.129

Septic arterial embolism, n (%)

35 (4.17)

103 (4.17)

0.999

35 (4.17)

23 (2.74)

0.109

Cardiogenic shock, n (%)

14 (1.67)

52 (2.11)

0.434

14 (1.67)

16 (1.91)

0.713

Dialysis, n (%)

64 (7.63)

105 (4.25)

 < 0.001

64 (7.63)

33 (3.93)

0.001

Heart valve surgery (aortic, mitral, tricuspid, pulmonary), n (%)

121 (14.42)

414 (16.77)

0.111

121 (14.42)

108 (12.87)

0.355

Mechanical ventilation, n (%)

87 (10.37)

254 (10.29)

0.946

87 (10.37)

74 (8.82)

0.281

Pacemaker implantation, n (%)

41 (4.89)

97 (3.93)

0.231

41 (4.89)

32 (3.81)

0.290

LOHS, Median (IQR)

18 (25)

18 (26)

0.778

18 (25)

18 (26)

0.823

IHM, n (%)

190 (22.65)

498 (20.17)

0.127

190 (22.65)

187 (22.29)

0.861

  1. T2DM: Type 2 diabetes mellitus; CCI: Charlson comorbidity index; COPD: chronic obstructive pulmonary disease; LOHS: Length of hospital stay; IHM: in-hospital mortality