Table 4 CVD and CKD risk factors at baseline (Prescribed Patient Set)
HCP specialty | Endocrinologist | Diabetologist | Cardiologist | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Study medication and characteristic | Empa N = 815 | DPP4i N = 504 | GLP-1 RA N = 89 | Other SGLT2i N = 244 | Total N = 1652 | Empa N = 1073 | DPP4i N = 624 | GLP-1 RA N = 271 | Other SGLT2i N = 333 | Total N = 2301 | Empa N = 78 | DPP4i N = 16 | GLP-1 RA N = 1 | Other SGLT2i N = 7 | Total N = 102 |
(A) Categorically assessed CVD and CKD risk factors | |||||||||||||||
BMI (%) | |||||||||||||||
Overweight | 25.6 | 36.5 | 11.2 | 18.9 | 27.2 | 23.4 | 37.2 | 10.7 | 25.5 | 25.9 | 37.2 | 43.8 | 100 | 42.9 | 39.2 |
Obese | 72.0 | 56.0 | 87.6 | 78.3 | 68.9 | 72.2 | 51.9 | 86.3 | 68.8 | 67.9 | 55.1 | 50 | 0 | 57.1 | 53.9 |
Hypertension (%) | 87.5 | 83.7 | 85.4 | 83.2 | 85.6 | 85.6 | 80.0 | 85.6 | 82.6 | 83.7 | 89.7 | 100 | 100 | 85.7 | 91.2 |
Unknown | 0.4 | 0.2 | 0 | 0.4 | 0.3 | 1.1 | 1.6 | 1.8 | 0.6 | 1.3 | 0 | 0 | 0 | 0 | 0 |
Never smoked (%) | 52.9 | 66.3 | 52.8 | 58.2 | 57.7 | 43.7 | 54.2 | 56.1 | 48.0 | 48.6 | 46.2 | 50 | 100 | 71.4 | 49.0 |
Unknown | 4.8 | 4.8 | 4.5 | 7.0 | 5.1 | 13.4 | 9.6 | 6.3 | 8.4 | 10.8 | 1.3 | 6.3 | 0 | 0 | 2.0 |
Physically inactive (%)* | 57.4 | 52.6 | 59.6 | 50.4 | 55.0 | 43.1 | 48.1 | 50.6 | 54.7 | 47 | 50.0 | 93.8 | 100 | 57.1 | 56.9 |
Unknown | 5.0 | 10.1 | 4.5 | 9.4 | 7.2 | 7.5 | 6.9 | 5.9 | 3.3 | 6.5 | 1.2 | 0 | 0 | 14.3 | 2.0 |
Family history (%) | |||||||||||||||
Early onset heart disease | 37.6 | 29.4 | 39.3 | 32 | 34.3 | 25.7 | 18.1 | 23.3 | 22.2 | 22.9 | 46.2 | 18.8 | 0 | 0 | 38.2 |
Unknown | 18.5 | 27.2 | 18.0 | 22.1 | 21.7 | 27.0 | 23.7 | 25.5 | 31.8 | 26.6 | 6.4 | 6.3 | 0 | 14.3 | 6.9 |
Early onset kidney disease | 8.1 | 7.3 | 4.5 | 4.9 | 7.2 | 6.9 | 4.2 | 4.8 | 7.2 | 6.0 | 11.5 | 6.3 | 0 | 0 | 9.8 |
Unknown | 22.8 | 31.9 | 18.0 | 27.9 | 26.1 | 34.6 | 27.4 | 27.3 | 36.9 | 32.1 | 10.3 | 6.3 | 0 | 14.3 | 9.8 |
(B) Ten-year fatal CVD risk (SCORE Risk Chart) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
10 year fatal CVD risk, mean (SD) | 6.4 (5.7) | 5.6 (4.7) | 4.3 (3.7) | 6.0 (5.7) | 6.0 (5.3) | 7.0 (5.5) | 7.0 (5.9) | 5.4 (4.7) | 6.5 (5.1) | 6.7 (5.5) | 8.9 (7.7) | 9.4 (7.8) | 5.0 | 3.8 (2.3) | 8.6 (7.5) |
Missing (%) | 24.5 | 20.0 | 30.3 | 26.6 | 23.8 | 43.2 | 43.1 | 42.8 | 50.8 | 44.2 | 30.8 | 31.3 | 0 | 28.6 | 30.4 |