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Table 2 Patient characteristics at baseline by HCP specialty (Prescribed Patient Set)

From: Real-world characteristics, modern antidiabetic treatment patterns, and comorbidities of patients with type 2 diabetes in central and Eastern Europe: retrospective cross-sectional and longitudinal evaluations in the CORDIALLY® study

HCP specialty

Endocrinologist

Diabetologist

Cardiologist

Study medication and characteristic

Empa

N = 815

DPP4i

N = 504

GLP-1 RA

N = 89

Other SGLT2i

N = 244

Total

N = 1652

Empa

N = 1073

DPP4i

N = 624

GLP-1 RA

N = 271

Other SGLT2i

N = 333

Total

N = 2301

Empa

N = 78

DPP4i

N = 16

GLP-1 RA

N = 1

Other SGLT2i

N = 7

Total

N = 102

(A) Demographics and clinical parameters relevant to T2D

 Age (years), mean (SD)

61.5 (9.7)

65.3 (10.4)

55.8 (10.5)

62.0 (9.2)

62.4 (10.2)

63.0 (9.4)

67.2 (11.0)

59.2 (10.8)

62.3 (9.2)

63.6 (10.3)

64.4 (8.4)

70.9 (9.5)

54.0

65.0 (9.4)

65.3 (8.9)

 Female (%)

53.0

66.3

41.6

57.4

57.1

40.4

47.6

49.8

42.0

43.7

44.9

50.0

0

28.6

44.1

 BMI (kg/m2), mean (SD)

33.3 (5.4)

31.3 (5.2)

36.7 (5.9)

34.3 (5.8)

33.0 (5.6)

33.3 (5.9)

31.0 (5.4)

36.2 (6.7)

32.8 (5.3)

33.0 (6.0)

30.8 (4.6)

29.9 (4.2)

25.8

30.7 (2.3)

30.6 (4.4)

 Non-black (%)a

98.8

98.6

98.9

98.0

98.6

99.7

100

99.6

100

99.8

100

100

100

100

100

 Years since T2D diagnosis, mean (SD)

9.1 (6.6)

9.1 (6.6)

9.2 (6.9)

9.8 (6.7)

9.2 (6.6)

10.7 (7.3)

10.4 (7.3)

10.1 (6.6)

10.1 (6.8)

10.5 (7.2)

6.7 (4.0)

9.7 (5.7)

6.0

10.9 (6.5)

7.5 (4.7)

 HbA1c (%), mean (SD)

8.5 (1.4)

8.1 (1.2)

8.2 (1.1)

8.5 (1.3)

8.4 (1.3)

8.2 (1.3)

7.9 (1.4)

8.4 (1.2)

8.6 (1.6)

8.2 (1.4)

7.9 (1.1)

8.1 (1.1)

7.4

8.5 (0.7)

8.0 (1.1)

 HbA1c ≥ 8.5% (%)

42.8

27.4

32.6

39.8

37.1

25.9

19.7

35.1

34.2

26.5

17.9

25.0

0

28.6

19.6

  Missing HbA1c (%)

1.6

5.4

4.5

3.7

3.2

14.3

7.7

5.2

10.8

10.9

35.9

6.3

0

28.6

30.4

(B) Clinical parameters relevant to CVD

 Systolic BP (mmHg), mean (SD)

136.8 (14.4)

134.3 (13.5)

134.5 (12.7)

135.6 (14.4)

135.7 (14.1)

137.5 (16.2)

138.6 (16.5)

137.2 (14.5)

137.9 (14.6)

137.8 (15.9)

140.6 (16.8)

140.4 (24.4)

165.0

120.4 (10.4)

139.6 (18.7)

 Diastolic BP (mmHg), mean (SD)

83.5 (7.8)

81.6 (7.8)

83.7 (8.5)

82.6 (8.2)

82.8 (8.0)

80.4 (9.5)

80.1 (9.8)

80.3 (9.6)

82.3 (9.0)

80.5 (9.5)

83.7 (10.8)

82.5 (13.0)

110.0

69.8 (10.0)

82.9 (11.9)

  Missing (%)

1.6

0.2

0

2.5

1.2

7.3

7.1

10.0

12.0

8.2

23.1

6.3

0

28.6

20.6

 LVEF (%), mean (SD)

59.5 (9.0)

61.7 (8.7)

63.2 (8.7)

58.1 (8.4)

59.9 (8.9)

54.0 (10.6)

59.3 (7.5)

57.7 (7.1)

59.8 (6.9)

56.6 (9.4)

56.0 (13.0)

43.8 (12.5)

32.0

48.3 (5.8)

52.8 (13.7)

 LVEF confirmed by echocardiography (%)

35.1

15.5

24.7

16.4

25.8

11.2

13.6

10.3

3.9

10.7

66.7

93.8

100

42.9

69.6

  Missing (%)

64.5

84.5

75.3

83.2

74.0

88.1

85.9

88.9

94.9

88.6

33.3

6.3

0

57.1

30.4

  Unknown (%)

0.4

0

0

0

0

0.6

0.5

0.4

0.6

0.5

0

0

0

0

0

 Total cholesterol (mml/L), mean (SD)

5.4 (1.2)

5.4 (1.2)

5.4 (1.3)

5.6 (1.2)

5.4 (1.2)

4.6 (1.1)

4.6 (1.1)

4.7 (1.2)

4.6 (1.1)

4.6 (1.1)

4.9 (1.3)

4.0 (1.1)

5.1

3.4 (0.3)

4.7 (1.3)

  Missing (%)

19.3

16.3

23.6

21.7

18.9

36.6

36.1

33.2

45.3

37.3

29.5

18.8

0

28.6

27.5

 LDL (mml/L), mean (SD)

2.9 (1.0)

3.1 (1.1)

3.0 (1.1)

3.0 (1.1)

3.0 (1.1)

2.5 (1.0)

2.5 (0.9)

2.5 (0.9)

2.6 (0.9)

2.5 (1.0)

2.7 (1.0)

2.3 (1.0)

2.1

1.8 (0.2)

2.5 (1.0)

  Missing (%)

40.9

44.4

40.4

54.1

43.9

47.7

44.4

41.3

49.2

46.3

44.9

18.8

0

28.6

39.2

 HDL (mml/L), mean (SD)

1.3 (0.4)

1.2 (0.3)

1.3 (0.4)

1.2 (0.3)

1.3 (0.4)

1.2 (0.3)

1.2 (0.3)

1.1 (0.3)

1.2 (0.3)

1.2 (0.3)

1.2 (0.3)

1.2 (0.4)

1.0

0.9 (0.2)

1.2 (0.3)

  Missing (%)

45.3

48.6

43.8

57.4

48.0

47.7

43.4

41.0

48.0

45.8

43.6

25.0

0

28.6

39.2

 Triglycerides (mml/L), mean (SD)

2.0 (0.8)

1.9 (0.7)

2.0 (0.6)

2.1 (1.1)

2.0 (0.8)

1.9 (0.8)

1.8 (0.7)

2.2 (1.9)

2.0 (0.9)

1.9 (1.0)

1.8(0.7)

1.8(0.9)

3.0

2.0(0.5)

1.8(0.7)

  Missing (%)

32.3

37.7

38.2

44.3

36.0

43.3

40.2

35.8

47.4

42.2

38.5

18.8

0

28.6

34.3

(C) Clinical parameters relevant to CKD

 Serum creatinine (mmol/L), mean (SD)

83.9 (16.1)

92.2 (28.0)

82.6 (17.9)

79.3 (14.5)

85.7 (20.8)

82.0 (25.4)

92.9 (37.4)

78.1 (19.7)

78.7 (18.7)

84.1 (28.5)

82.3 (23.4)

94.6 (34.2)

67.0

60.4 (3.6)

82.8 (25.6)

 eGFR (ml/min), mean (SD)

75.9 (17.0)

67.7 (20.8)

84.3 (19.6)

78.8 (17.0)

74.3 (19.0)

80.4 (19.3)

71.5 (24.1)

84.0 (18.9)

83.3 (17.1)

78.8 (20.9)

78.7 (19.1)

67.2 (24.0)

103.6

101.1 (4.8)

78.5 (20.7)

  Missing (%)

8.5

11.3

15.7

12.7

10.4

29.7

30.1

30.6

35.1

30.7

24.4

18.8

0

28.6

23.5

 UACR (mg/g), mean (SD)

129.1 (139.5)

133.0 (137.5)

108.2 (131.0)

112.7 (137.2)

126.4 (137.8)

20.2 (38.7)

74.0 (300.8)

18.3 (56.3)

44.5 (117.8)

41.1 (187.3)

298.6 (133.8)

–

–

–

298.6 (133.8)

 UACR (mg/g), median (Q1, Q3)

68.0 (15.0, 235.0)

70.5 (10.0, 213.0)

45.0 (10.0, 203.0)

37.0 (12.3, 190.0)

69.3 (12.0, 223.0)

7.0 (1.6, 18.0)

4.8 (1.2, 17.8)

1.7 (0.6, 6.4)

7.0 (2.0, 32.9)

4.9 (1.2, 17.8)

282.0 (222.0, 405.0)

–

–

–

282.0 (222.0, 405.0)

  Missing (%)

74.6

75.2

70.0

73.4

74.3

84.2

76.1

76.4

90.1

81.9

89.7

100

100

100

92.2

  1. BP blood pressure, BMI body mass index, CKD chronic kidney disease, CVD cardiovascular disease, DPP4i dipeptidyl peptidase-4 inhibitor, eGFR estimated glomerular filtration rate, Empa empagliflozin, GLP-1 RA glucagon-like peptide-1 receptor agonist, HbA1c glycated haemoglobin, HCP healthcare professional, HDL high density lipoproteins, LDL low density lipoproteins, LVEF left ventricular ejection fraction, Q quartile, SD standard deviation, SGLT2i sodium-glucose cotransporter-2 inhibitor, T2D type 2 diabetes, UACR urine albumin-creatinine ratio.
  2. aAssessment of ethnicity (black or non-black) was necessary for calculation of eGFR (shown in Table 2c
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Cardiovascular Diabetology

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