Study medication and characteristic | Empa N = 1966 | DPP4i N = 1144 | GLP-1 RA N = 361 | Other SGLT2i N = 584 | Total N = 4055 |
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(A) Demographics and clinical parameters relevant to T2D | |||||
Age (years), mean (SD) | 62.4 (9.5) | 66.4 (10.8) | 58.3 (10.8) | 62.2 (9.2) | 63.1 (10.2) |
Female (%) | 45.8 | 55.9 | 47.6 | 48.3 | 49.1 |
BMI (kg/m2), mean (SD) | 33.2 (5.7) | 31.1 (5.3) | 36.3 (6.5) | 33.4 (5.6) | 32.9 (5.8) |
Non-black (%)a | 99.3 | 99.4 | 99.4 | 99.1 | 99.3 |
Years since T2D diagnosis, mean (SD) | 9.9 (7.0) | 9.8 (7.0) | 9.8 (6.7) | 10.0 (6.7) | 9.9 (6.9) |
HbA1c (%), mean (SD) | 8.3 (1.4) | 8.0 (1.3) | 8.4 (1.2) | 8.6 (1.5) | 8.3 (1.4) |
HbA1c ≥ 8.5% (%) | 32.6 | 23.2 | 34.3 | 36.5 | 30.7 |
Missing HbA1c (%) | 9.9 | 6.6 | 5.0 | 8.0 | 8.3 |
(B) Clinical parameters relevant to CVD | |||||
---|---|---|---|---|---|
Systolic BP (mmHg), mean (SD) | 137.3 (15.5) | 136.7 (15.5) | 136.6 (14.2) | 136.7 (14.6) | 137.0 (15.3) |
Diastolic BP (mmHg), mean (SD) | 81.8 (9.0) | 80.8 (9.0) | 81.3 (9.5) | 82.3 (8.8) | 81.6 (9.0) |
Missing (%) | 5.5 | 4.0 | 7.5 | 8.2 | 5.7 |
LVEF (%), mean (SD) | 57.6 (10.2) | 59.0 (9.7) | 59.5 (9.0) | 58.1 (8.1) | 58.1 (9.9) |
LVEF confirmed by echocardiography (%) | 23.3 | 15.6 | 14.1 | 9.6 | 18.3 |
Missing (%) | 76.1 | 84.2 | 85.3 | 89.6 | 81.2 |
Unknown (%) | 0.5 | 0.3 | 0.3 | 0.3 | 0.4 |
Total cholesterol (mml/L), mean (SD) | 5.0 (1.2) | 5.0 (1.2) | 4.9 (1.2) | 5.1 (1.3) | 5.0 (1.2) |
Missing (%) | 29.1 | 27.1 | 30.7 | 35.3 | 29.6 |
LDL (mml/L), mean (SD) | 2.7 (1.0) | 2.8 (1.1) | 2.6 (1.0) | 2.7 (1.0) | 2.7 (1.0) |
Missing (%) | 44.8 | 44.1 | 41.0 | 51.0 | 45.1 |
HDL (mml/L), mean (SD) | 1.2 (0.4) | 1.2 (0.3) | 1.2 (0.3) | 1.2 (0.3) | 1.2 (0.4) |
Missing (%) | 46.5 | 45.5 | 41.6 | 51.7 | 46.5 |
Triglycerides (mml/L), mean (SD) | 1.9 (0.8) | 1.9 (0.7) | 2.2 (1.7) | 2.0 (1.0) | 2.0 (0.9) |
Missing (%) | 38.6 | 38.8 | 36.3 | 45.9 | 39.5 |
(C) Clinical parameters relevant to CKD | |||||
---|---|---|---|---|---|
Serum creatinine (mmol/L), mean (SD) | 82.9 (21.4) | 92.6 (33.0) | 79.3 (19.2) | 78.8 (16.8) | 84.8 (25.1) |
eGFR (ml/min), mean (SD) | 78.2 (18.4) | 69.5 (22.6) | 84.1 (19.1) | 81.3 (17.2) | 76.7 (20.1) |
Missing (%) | 20.7 | 21.7 | 26.9 | 25.7 | 22.2 |
UACR (mg/g), mean (SD) | 84.6 (123.6) | 100.9 (241.9) | 45.0 (94.2) | 89.7 (134.3) | 86.2 (107.4) |
UACR (mg/g), median (Q1, Q3) | 20.0 (4.6, 125.0) | 12.7 (2.0, 123.0) | 4.4 (0.9, 28.0) | 23.5 (6.2, 96.0) | 15.0 (2.7, 109.1) |
Missing (%) | 80.4 | 76.0 | 74.8 | 83.2 | 79.1 |