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Table 3 Selected molecules of interest trapped inside the digested microclots of high-responder long COVID patients (N = 66) vs all controls (N = 29)

From: Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system

Immunoglobulin molecules (or fragments thereof) that were found to be INCREASED in the long COVID (high responder) sample vs the healthy sample

Uniprot ID

Molecule

Fold change

p-Value

P01876

Immunoglobulin alpha-1 chain C region

(IGHA1_HUMAN)

1.5

1.2 × 10− 05

A0A0C4DH32

Immunoglobulin heavy chain V-III region GAL

(HV320_HUMAN)

1.6

5 × 10− 05

P01602

Immunoglobulin kappa chain V-I region HK102 (Fragment) (KV105_HUMAN)

1.6

0.0003

B9A064

Immunoglobulin lambda-like polypeptide 5

(IGLL5_HUMAN)

1.7

2.5 × 10− 11

P01717

Immunoglobulin lambda chain V-IV region Hil

(LV403_HUMAN)

1.8

1.7 × 10− 05

P01763

Immunoglobulin heavy chain V-III region WEA

(HV348_HUMAN)

1.9

0.005

P01764

Immunoglobulin heavy chain V-III region TUR

(HV323_HUMAN)

2.1

2.4 × 10− 05

P04433

Immunoglobulin kappa chain V-III region VG (Fragment) (KV311_HUMAN)

2.4

1.5 × 10− 13

P04207

Immunoglobulin kappa chain V-III region CLL (B chronic lymphocytic leukaemia) [32] (KV315_HUMAN)

CD5- B cell CLL cell population might produce pathologic IgM kappa rheumatoid factor autoantibodies [33]

2.3

2.9 × 10− 08

P01624

Immunoglobulin kappa chain V-III region POM (plasma membrane)

(KV315_HUMAN) rheumatoid factor

2.3

0.01

P04211

Immunoglobulin lambda chain V region 4A

(LV743_HUMAN)

2.5

0.003

P06331

Immunoglobulin heavy chain V-II region ARH-77 (HV434_HUMAN)

2.7

0.002

P04430

Immunoglobulin kappa chain V-I region BAN

(KV116_HUMAN)

2.8

2.7 × 10− 06

P01762

Immunoglobulin heavy chain V-III region TRO

(HV311_HUMAN)

2.8

1.0 × 10− 08

P01619

Immunoglobulin kappa chain V-III region NG9 (Fragment) (KV320_HUMAN)

2.9

7.3 × 10− 05

P01619

Immunoglobulin kappa chain V-III region B6

(KV320_HUMAN)

3.8

4.1 × 10− 06

P80748

Immunoglobulin lambda chain V-V region DEL

(LV321_HUMAN)

3.8

1.2 × 10− 08

P01780

Immunoglobulin heavy chain V-III region JON

(HV307_HUMAN)

4.0

0.002

P01772

Immunoglobulin heavy chain V-III region KOL

(HV333_HUMAN)

4.2

1.1 × 10− 05

P01700

Immunoglobulin lambda chain V-I region HA

(LV147_HUMAN)

4.6

2.3 × 10− 06

P01767

Immunoglobulin heavy chain V-III region BUT

(HV353_HUMAN)

5.0

1.8 × 10− 06

P06312

Immunoglobulin kappa chain V-IV region Len

(KV401_HUMAN)

5.6

9.9 × 10− 21

P01700

Immunoglobulin lambda chain V-I region WAH

(LV147_HUMAN)

14.8

2.4 × 10− 08

P01593

Immunoglobulin kappa chain V-I region Ni

(KVD33_HUMAN)

76.0

4.5 × 10− 42

  1. Fold changes and P values of immunoglobulin molecules (or fragments thereof) that were found to be increased in the long COVID high responder population compared to our healthy controls are shown here (p = 0.01). Immunoglobulin molecules are either present or absent and therefore we only listed molecules (or fragments thereof) that were noted to be increased. We excluded immunoglobulin molecules (or fragments thereof) that were reduced compared to our healthy controls. Descriptions of the molecules are taken from the Uniprot website and were added in the description column. After cross referencing each immunoglobulin on THE INTERNATIONAL IMMUNOGENETICS INFORMATION SYSTEM®’s IMGT/LIGM-DB database a datafile containing a description of the immunoglobulin, the nucleotide sequence, other data and literature references can be downloaded. The descriptions listed below were obtained from these data files
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Cardiovascular Diabetology

ISSN: 1475-2840