Fig. 6

Assessment of [Ca²⁺]_SR by measurement of caffeine-induced CaTs. a Representative recording of caffeine-induced CaTs from a single RVCM for the 4 groups (caffeine = 10 mmol/L), which was used to estimate the total [Ca²⁺]_SR content. b CaT amplitude. c CaT decay time constant. Each point represents the result from a single RVCM. RVCM right ventricular cardiomyocyte, CaT Ca²⁺ transient, [Ca²⁺]_SR sarcoplasmic reticulum Ca²⁺ content. n/N = 15/5 = cells/rats per group. The horizontal lines show the mean ± SEM. One-way ANOVA or the nonparametric Wilcoxon signed-rank test. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001