| Model 1 | Model 2 | Model 3 | ||||
---|---|---|---|---|---|---|---|
Event/total (%) | HR (95%CI) | p value | HR (95%CI) | p value | HR (95%CI) | p value | |
Cardiovascular disease | |||||||
 Low | 32/1810 (1.8) | Reference | – | Reference | – | Reference | – |
 Moderate | 79/1910 (4.1) | 2.23 (1.47, 3.39) |  < 0.001 | 1.58 (1.02, 2.45) | 0.038 | 1.58 (1.02, 2.45) | 0.039 |
 High | 37/418 (8.9) | 4.88 (2.98, 7.98) |  < 0.001 | 2.36 (1.35, 4.14) | 0.002 | 2.35 (1.34, 4.12) | 0.002 |
 p for trend |  |  < 0.001 |  | 0.001 |  | 0.005 |  |
All-cause mortality | |||||||
 Low | 45/1810 (2.5) | Reference | – | Reference | – | Reference | – |
 Moderate | 95/1910 (5.0) | 1.87 (1.30, 2.69) |  < 0.001 | 1.80 (1.23, 2.62) | 0.002 | 1.74 (1.19, 2.53) | 0.003 |
 High | 37/418 (8.9) | 3.39 (2.15, 5.33) |  < 0.001 | 3.21 (1.93, 5.33) |  < 0.001 | 3.04 (1.83, 5.07) |  < 0.001 |
 p for trend |  |  < 0.001 |  |  < 0.001 |  |  < 0.001 |  |