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Table 3 Risk of incident cardiovascular disease and mortality by TyG index trajectory groups

From: High triglyceride-glucose index in young adulthood is associated with incident cardiovascular disease and mortality in later life: insight from the CARDIA study

 

Model 1

Model 2

Model 3

Event/total (%)

HR (95%CI)

p value

HR (95%CI)

p value

HR (95%CI)

p value

Cardiovascular disease

 Low

32/1810 (1.8)

Reference

–

Reference

–

Reference

–

 Moderate

79/1910 (4.1)

2.23 (1.47, 3.39)

 < 0.001

1.58 (1.02, 2.45)

0.038

1.58 (1.02, 2.45)

0.039

 High

37/418 (8.9)

4.88 (2.98, 7.98)

 < 0.001

2.36 (1.35, 4.14)

0.002

2.35 (1.34, 4.12)

0.002

 p for trend

 

 < 0.001

 

0.001

 

0.005

 

All-cause mortality

 Low

45/1810 (2.5)

Reference

–

Reference

–

Reference

–

 Moderate

95/1910 (5.0)

1.87 (1.30, 2.69)

 < 0.001

1.80 (1.23, 2.62)

0.002

1.74 (1.19, 2.53)

0.003

 High

37/418 (8.9)

3.39 (2.15, 5.33)

 < 0.001

3.21 (1.93, 5.33)

 < 0.001

3.04 (1.83, 5.07)

 < 0.001

 p for trend

 

 < 0.001

 

 < 0.001

 

 < 0.001

 
  1. Model 1 Adjusted by sex, age, race
  2. Model 2 Adjusted by model 1 + body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, smoking status, drinking status, education level, total physical activity
  3. Model 3 Adjusted by model 2 + diabetes, family history of diabetes, hypertension, any antihypertensive use
  4. TyG triglyceride-glucose, HR hazard ratio, CI confidence interval