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Table 2 Univariate/multivariable multilevel logistic analysis for mortality and readmission in the prevalent DM cohort

From: Contemporary use of SGLT2 inhibitors in heart failure patients with diabetes mellitus: a comparison of DPP4 inhibitors in a nationwide electric health database of the superaged society

 

Univariate

Model 1

Model 2

Matched model

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

Mortality

 Overall

  DPP4 inhibitor

Ref

Ref

Ref

Ref

  SGLT2 inhibitor

0.44 (0.37,0.52)

0.62(0.52,0.74)

0.67 (0.56,0.80)

0.70 (0.56,0.89)

  Both inhibitors

0.49 (0.42,0.56)

0.65 (0.56,0.74)

0.71 (0.62,0.82)

 

 Patients ≥ 75 years

  DPP4 inhibitor

Ref

Ref

Ref

Ref

  SGLT2 inhibitor

0.56 (0.45,0.69)

0.59 (0.48,0.74)

0.64 (0.52,0.80)

0.68 (0.51,0.90)

  Both inhibitors

0.58 (0.49,0.69)

0.63 (0.53,0.75)

0.69 (0.58,0.82)

 

HF readmission

 Overall

  DPP4 inhibitor

Ref

Ref

Ref

Ref

  SGLT2 inhibitor

0.43 (0.38,0.48)

0.48 (0.42,0.54)

0.50 (0.44,0.56)

0.52 (0.45,0.61)

  Both inhibitors

0.49 (0.45,0.54)

0.53 (0.49,0.59)

0.56 (0.51,0.62)

 

 Patients ≥ 75 years

  DPP4 inhibitor

Ref

Ref

Ref

Ref

  SGLT2 inhibitor

0.54 (0.46,0.63)

0.53 (0.45,0.62)

0.54 (0.46,0.64)

0.59 (0.47,0.74)

  Both inhibitors

0.53 (0.46,0.60)

0.52 (0.46,0.60)

0.55 (0.48,0.62)

 

All-cause readmission

 Overall

  DPP4 inhibitor

Ref

Ref

Ref

Ref

  SGLT2 inhibitor

0.63 (0.59,0.67)

0.65 (0.61,0.69)

0.68 (0.63,0.72)

0.72 (0.66,0.79)

  Both inhibitors

0.74 (0.70,0.78)

0.76 (0.72,0.80)

0.78 (0.74,0.83)

 

 Patients ≥ 75 years

  DPP4 inhibitor

Ref

Ref

Ref

Ref

  SGLT2 inhibitor

0.70 (0.64,0.77)

0.69 (0.63,0.76)

0.71 (0.64,0.78)

0.76 (0.65,0.87)

  Both inhibitors

0.76 (0.71,0.82)

0.75 (0.69,0.81)

0.77 (0.71,0.83)

 
  1. In Model 1, HR was adjusted for age category and sex. In Model 2, HR was adjusted for age category, sex, and other 22 factors
  2. CI, confidence interval; DPP4, dipeptidyl peptidase-4; HF, heart failure; HR, hazard ratio; SGLT2, sodium–glucose cotransporter-2