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Table 2 Baseline characteristics of the study population according to the tertiles of the TyG index

From: Triglyceride-glucose index in the prediction of adverse cardiovascular events in patients with premature coronary artery disease: a retrospective cohort study

Variables

Tertile 1 (n = 175)

Tertile 2 (n = 176)

Tertile 3 (n = 175)

p-value

TyG index

8.18 ± 0.26

8.72 ± 0.13

9.39 ± 0.36

 < 0.001

General conditions

 Age (years)

45.22 ± 6.27

43.35 ± 6.03

44.89 ± 6.48

0.012

 Male, n (%)

98 (56.0)

117 (66.5)

101 (57.7)

0.099

 BMI (kg/m2)

26.25 ± 2.98

26.98 ± 3.49

27.47 ± 3.49

0.003

 LVEF (%)

59.13 ± 10.84

59.81 ± 9.80

59.66 ± 9.32

0.799

 Admission for MI, n (%)

36 (20.6)

63 (35.8)

54 (30.9)

0.006

 GS

31.00 (17.00–52.00)

36.50 (22.00–59.50)

45.00 (27.00–65.00)

 < 0.001

 Multivessel disease, n (%)

73 (41.7)

82 (46.6)

78 (44.6)

0.653

Risk factors, n (%)

 Current smoking

43 (24.6)

51 (29.0)

54 (30.9)

0.406

 Current drinking

31 (17.7)

39 (22.2)

29 (16.6)

0.367

 FH-CAD

27 (15.4)

48 (27.3)

69 (39.4)

 < 0.001

 DM

11 (6.3)

24 (13.6)

68 (38.9)

 < 0.001

 Hypertension

94 (53.7)

107 (60.8)

98 (56.0)

0.393

 Hyperlipidemia

15 (8.6)

63 (35.8)

98 (56.0)

 < 0.001

Laboratory test

 FPG (mmol/L)

4.54 (4.17–4.89)

4.91 (4.57–5.73)

5.81 (5.06–7.97)

 < 0.001

 TC (mmol/L)

3.73 (3.12–4.26)

4.02 (3.37–4.77)

4.57 (3.70–5.35)

 < 0.001

 TG (mmol/L)

1.01 (0.84–1.19)

1.49 (1.32–1.80)

2.21 (1.79–2.71)

 < 0.001

 LDL-C (mmol/L)

2.27 (1.71–2.69)

2.54 (2.00–3.13)

2.85 (2.07–3.54)

 < 0.001

 HDL-C (mmol/L)

1.20 ± 0.26

1.16 ± 0.23

1.17 ± 0.27

0.495

 eGFR (mL/min/1.73m2)

118.55 ± 24.11

116.47 ± 27.53

119.18 ± 26.25

0.595

 UA (μmol/L)

310.26 ± 80.11

324.40 ± 87.37

331.10 ± 95.52

0.078

Cardiovascular medications, n (%)

 Antiplatelet drugs

164 (93.7)

168 (95.5)

165 (94.3)

0.767

 Stains

168 (96.0)

164 (93.2)

169 (96.6)

0.279

 Beta-blockers

103 (58.9)

111 (63.1)

108 (61.7)

0.711

 ACEI/ARB

62 (35.4)

91 (51.7)

93 (53.1)

0.001

 Hypoglycemic drugs

11 (6.3)

19 (10.8)

60 (34.3)

 < 0.001

Outcomes, n (%)

 MACE

20 (11.4)

36 (20.5)

45 (25.7)

0.003

 All-cause death

2 (1.1)

1 (0.6)

3 (1.7)

0.543

 Cardiovascular death

1 (0.6)

1 (0.6)

3 (1.7)

0.544

 Non-fatal MI

5 (2.9)

10 (5.7)

14 (8.0)

0.108

 Coronary artery revascularization

12 (6.9)

23 (13.1)

27 (15.4)

0.037

 Non-fatal stroke

1 (0.6)

2 (1.1)

1 (0.6)

1.000

  1. Data were given as mean ± SD, median with interquartile range or n (%)
  2. TyG index, triglyceride-glucose index, BMI body mass index, LVEF left ventricle ejection fraction, MI myocardial infarction, GS Gensini score, FH-CAD family history of coronary artery disease, DM diabetes mellitus, FPG fasting plasma glucose, TC total cholesterol, TG triglyceride, LDL-C low-density lipoprotein-cholesterol, HDL-C high-density lipoprotein-cholesterol, eGFR estimated glomerular filtration rate, UA uric acid, ACEI angiotensin-converting enzyme inhibitors, ARB angiotensin receptor blockers, MACE major adverse cardiovascular events
  3. p values in bold are < 0.05