Table 3 Hazard Ratio (95% CI) from subgroup analyses for risks of CVD events at pre-defined levels of HbA1c

By sex

 Male

1013/6143

0.76 (0.54–1.07)

0.64 (0.51–0.80)

0.68 (0.57–0.81)

0.85 (0.78–0.93)

0.95 (0.91–0.99)

Ref.

1.05 (0.99–1.10)

1.09 (0.98–1.21)

 Female

82/542

1.38 (0.32–6.05)

1.09 (0.44–2.66)

0.90 (0.40–2.02)

0.92 (0.65–1.30)

0.96 (0.85–1.08)

Ref.

1.04 (0.91–1.20)

1.09 (0.82–1.43)

By age

  < 65 years

635/4702

0.67 (0.43–1.03)

0.64 (0.48–0.85)

0.72 (0.58–0.89)

0.87 (0.79–0.96)

0.96 (0.91–1.01)

Ref.

1.04 (0.98–1.10)

1.08 (0.96–1.21)

  ≥ 65 years

460/1983

0.75 (0.45–1.27)

0.57 (0.41–0.80)

0.55 (0.41–0.74)

0.76 (0.64–0.89)

0.91 (0.83–1.01)

Ref.

1.08 (0.97–1.20)

1.16 (0.94–1.44)

By diabetes mellitus

 Without diabetes

831/5840

0.86 (0.59–1.25)

0.69 (0.55–0.87)

0.76 (0.63–0.92)

0.92 (0.79–1.07)

0.96 (0.89–1.04)

Ref.

1.04 (0.96–1.12)

1.08 (0.93–1.26)

 With diabetes

264/845

1.00 (0.42–2.36)

0.94 (0.53–1.65)

0.88 (0.64–1.22)

0.85 (0.65–1.11)

0.90 (0.76–1.06)

Ref.

1.10 (1.01–1.20)

1.20 (1.05–1.38)

By MH status

 MH

46/572

0.60 (0.10–3.53)

0.39 (0.10–1.51)

0.44 (0.11–1.77)

0.59 (0.20–1.74)

0.77 (0.45–1.32)

Ref.

1.30 (0.76–2.23)

1.70 (0.58–5.00)

 MU

1039/6088

0.61 (0.44–0.85)

0.50 (0.42–0.60)

0.53 (0.46–0.62)

0.76 (0.71–0.82)

0.92 (0.88–0.96)

Ref.

1.06 (1.01–1.11)

1.13 (1.03–1.24)