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Table 2 Association between tertiles of baseline, mean, and variability of TyG index and incidence of cardiovascular disease

From: Triglyceride-glucose index variability and incident cardiovascular disease: a prospective cohort study

  Hazard ratio (95% CI)a P for trendb
Tertile 1 Tertile 2 Tertile 3
Baseline TyG index
 No. of cases/population 594/16532 827/16521 983/16526  
 Incidence rate per 1000 person-years 4.18 5.82 6.95  
 Model 1c 1 [Reference] 1.41 (1.27–1.56) 1.81 (1.64–2.01)  < 0.001
 Model 2d 1 [Reference] 1.29 (1.15–1.44) 1.37 (1.22–1.54)  < 0.001
 Model 3e 1 [Reference] 1.22 (1.09–1.37) 1.25 (1.11–1.42)  < 0.001
Mean TyG index
 No. of cases/population 548/16527 817/16526 1039/16526  
 Incidence rate per 1000 person-years 3.85 5.75 7.35  
 Model 1c 1 [Reference] 1.49 (1.34–1.66) 2.00 (1.81–2.22)  < 0.001
 Model 2d 1 [Reference] 1.33 (1.18–1.49) 1.51 (1.35–1.70)  < 0.001
 Model 3e 1 [Reference] 1.26 (1.13–1.42) 1.40 (1.24–1.58)  < 0.001
TyG variability
 No. of cases/population 766/16527 794/16526 844/16526  
 Incidence rate per 1000 person-years 5.03 5.59 5.94  
 Model 1c 1 [Reference] 1.07 (0.97–1.18) 1.19 (1.08–1.31)  < 0.001
 Model 2d 1 [Reference] 1.03 (0.93–1.15) 1.13 (1.02–1.25) 0.017
 Model 3e 1 [Reference] 1.04 (0.94–1.15) 1.13 (1.02–1.25) 0.021
 Model 4f 1 [Reference] 1.04 (0.94–1.15) 1.12 (1.01–1.24) 0.030
  1. TyG triglyceride-glucose, CI confidence interval
  2. aThe tertiles cutoff were < 8.4, 8.4 to 8.9, > 8.9 for baseline TyG index, < 8.4, 8.4 to 8.8, > 8.8 for mean TyG index, and < 0.15, 0.15 to 0.35, > 0.35 for TyG index variability
  3. bP value from linear trend test when tertiles were treated as an ordinal variable in the Cox model
  4. cAdjusted for age and sex
  5. dAdjusted for age, sex, education, income, current smoking, current drinking, physical activity, body mass index, diabetes, hypertension, chronic kidney disease, and high-sensitivity C-reactive protein
  6. eAdjusted for covariates in model 2 plus hypercholesterolaemia, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol
  7. fAdjusted for covariates in model 3 plus baseline TyG index