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Table 2 Association between tertiles of baseline, mean, and variability of TyG index and incidence of cardiovascular disease

From: Triglyceride-glucose index variability and incident cardiovascular disease: a prospective cohort study

 

Hazard ratio (95% CI)a

P for trendb

Tertile 1

Tertile 2

Tertile 3

Baseline TyG index

 No. of cases/population

594/16532

827/16521

983/16526

 

 Incidence rate per 1000 person-years

4.18

5.82

6.95

 

 Model 1c

1 [Reference]

1.41 (1.27–1.56)

1.81 (1.64–2.01)

 < 0.001

 Model 2d

1 [Reference]

1.29 (1.15–1.44)

1.37 (1.22–1.54)

 < 0.001

 Model 3e

1 [Reference]

1.22 (1.09–1.37)

1.25 (1.11–1.42)

 < 0.001

Mean TyG index

 No. of cases/population

548/16527

817/16526

1039/16526

 

 Incidence rate per 1000 person-years

3.85

5.75

7.35

 

 Model 1c

1 [Reference]

1.49 (1.34–1.66)

2.00 (1.81–2.22)

 < 0.001

 Model 2d

1 [Reference]

1.33 (1.18–1.49)

1.51 (1.35–1.70)

 < 0.001

 Model 3e

1 [Reference]

1.26 (1.13–1.42)

1.40 (1.24–1.58)

 < 0.001

TyG variability

 No. of cases/population

766/16527

794/16526

844/16526

 

 Incidence rate per 1000 person-years

5.03

5.59

5.94

 

 Model 1c

1 [Reference]

1.07 (0.97–1.18)

1.19 (1.08–1.31)

 < 0.001

 Model 2d

1 [Reference]

1.03 (0.93–1.15)

1.13 (1.02–1.25)

0.017

 Model 3e

1 [Reference]

1.04 (0.94–1.15)

1.13 (1.02–1.25)

0.021

 Model 4f

1 [Reference]

1.04 (0.94–1.15)

1.12 (1.01–1.24)

0.030

  1. TyG triglyceride-glucose, CI confidence interval
  2. aThe tertiles cutoff were < 8.4, 8.4 to 8.9, > 8.9 for baseline TyG index, < 8.4, 8.4 to 8.8, > 8.8 for mean TyG index, and < 0.15, 0.15 to 0.35, > 0.35 for TyG index variability
  3. bP value from linear trend test when tertiles were treated as an ordinal variable in the Cox model
  4. cAdjusted for age and sex
  5. dAdjusted for age, sex, education, income, current smoking, current drinking, physical activity, body mass index, diabetes, hypertension, chronic kidney disease, and high-sensitivity C-reactive protein
  6. eAdjusted for covariates in model 2 plus hypercholesterolaemia, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol
  7. fAdjusted for covariates in model 3 plus baseline TyG index