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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study

Fig. 4

A Nomogram for predicting 5-, 10-, and 15-year overall survival in patients with type 2 diabetes based on sex, age, systolic blood pressure (mmHg), HbA1c (%), and the AGEs/cRAGE ratio. The points assigned to each variable are summed up to obtain the total points, and a vertical line can be drawn from the total points to obtain the corresponding survival probability. B Performance of the model based on the internal validation. Model area under the curves (AUCs) at each year are displayed. The solid line represents the mean of the AUC, the dashed line represents the median of the AUC. The darker interval in the plot shows the 25% and 75% quantiles of AUC, the lighter interval shows the minimum and maximum of AUC. C Plot of the observed against the predicted 15-year survival probability for patients with type 2 diabetes grouped according to risk quartiles. The grey diagonal line represents perfect calibration. D Kaplan-Meier survival function for patients with type 2 diabetes grouped according to quartiles of the nomogram-based mortality risk score

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Cardiovascular Diabetology

ISSN: 1475-2840